The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance.
The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance.
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DOI：
10.1016/j.celrep.2021.110218
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发表时间：
2022-01-11
期刊：
影响因子：
8.8
通讯作者：
Sato K
中科院分区：
文献类型：
--
作者：
Kimura I;Kosugi Y;Wu J;Zahradnik J;Yamasoba D;Butlertanaka EP;Tanaka YL;Uriu K;Liu Y;Morizako N;Shirakawa K;Kazuma Y;Nomura R;Horisawa Y;Tokunaga K;Ueno T;Takaori-Kondo A;Schreiber G;Arase H;Genotype to Phenotype Japan (G2P-Japan) Consortium;Motozono C;Saito A;Nakagawa S;Sato K
我们感兴趣的变体SARS-CoV-2 Lambda已在一些南美国家传播；然而，其病毒学特征和进化特征尚不清楚。在这项研究中，我们使用假病毒，发现由于T76I和L452Q突变，Lambda变异体的刺突蛋白比其他变异体更具传染性。RSYLTPGD246-253N突变是Lambda刺突蛋白n端独特的7个氨基酸缺失，负责逃避中和抗体，并进一步增强抗体介导的感染增强。尽管这种突变产生了一个新生的n -链糖基化位点，但额外的n -链聚糖对于这种突变所赋予的病毒学特性是必不可少的。由于携带RSYLTPGD246-253N突变的分离株的频率不断增加，Lambda变体的传播占主导地位，因此我们的数据表明，RSYLTPGD246-253N突变与Lambda变体在南美的大量传播密切相关。Kimura等人揭示了我们感兴趣的SARS-CoV-2 Lambda变体的特征。由于T76I和L452Q突变，λ刺突比其他变异更具传染性。RSYLTPGD246-253N突变负责逃避中和抗体，并进一步增强抗体介导的感染增强。
SARS-CoV-2 Lambda, a variant of interest, has spread in some South American countries; however, its virological features and evolutionary traits remain unclear. In this study, we use pseudoviruses and reveal that the spike protein of the Lambda variant is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation, a unique 7-amino acid deletion in the N-terminal domain of the Lambda spike protein, is responsible for evasion from neutralizing antibodies and further augments antibody-mediated enhancement of infection. Although this mutation generates a nascent N-linked glycosylation site, the additional N-linked glycan is dispensable for the virological property conferred by this mutation. Since the Lambda variant has dominantly spread according to the increasing frequency of the isolates harboring the RSYLTPGD246-253N mutation, our data suggest that the RSYLTPGD246-253N mutation is closely associated with the substantial spread of the Lambda variant in South America. Kimura et al. reveal the characteristics of the SARS-CoV-2 Lambda variant of interest. Lambda spike is more infectious than that of other variants due to the T76I and L452Q mutations. The RSYLTPGD246-253N mutation is responsible for evasion from neutralizing antibodies and further augments antibody-mediated enhancement of infection.
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DOI：
10.1093/infdis/jiab368
发表时间：
2021-09-17
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Ferreira IATM;Kemp SA;Datir R;Saito A;Meng B;Rakshit P;Takaori-Kondo A;Kosugi Y;Uriu K;Kimura I;Shirakawa K;Abdullahi A;Agarwal A;Ozono S;Tokunaga K;Sato K;Gupta RK;CITIID-NIHR BioResource COVID-19 Collaboration, Indian SARS-CoV-2 Genomics Consortium;Genotype to Phenotype Japan (G2P-Japan) Consortium
通讯作者：
Genotype to Phenotype Japan (G2P-Japan) Consortium
影响因子：
64.5
作者：
Hoffmann M;Arora P;Groß R;Seidel A;Hörnich BF;Hahn AS;Krüger N;Graichen L;Hofmann-Winkler H;Kempf A;Winkler MS;Schulz S;Jäck HM;Jahrsdörfer B;Schrezenmeier H;Müller M;Kleger A;Münch J;Pöhlmann S
通讯作者：
Pöhlmann S
影响因子：
64.5
作者：
Garcia-Beltran, Wilfredo F.;Lam, Evan C.;Balazs, Alejandro B.
通讯作者：
Balazs, Alejandro B.
DOI：
10.1126/science.abi6226
发表时间：
2021-08-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gobeil SM;Janowska K;McDowell S;Mansouri K;Parks R;Stalls V;Kopp MF;Manne K;Li D;Wiehe K;Saunders KO;Edwards RJ;Korber B;Haynes BF;Henderson R;Acharya P
通讯作者：
Acharya P
DOI：
10.1056/nejmoa2105000
发表时间：
2021-06-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hacisuleyman E;Hale C;Saito Y;Blachere NE;Bergh M;Conlon EG;Schaefer-Babajew DJ;DaSilva J;Muecksch F;Gaebler C;Lifton R;Nussenzweig MC;Hatziioannou T;Bieniasz PD;Darnell RB
通讯作者：
Darnell RB