SARS-CoV-2 B.1.617 Mutations L452R and E484Q Are Not Synergistic for Antibody Evasion.
SARS-CoV-2 B.1.617 Mutations L452R and E484Q Are Not Synergistic for Antibody Evasion.
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DOI：
10.1093/infdis/jiab368
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发表时间：
2021-09-17
期刊：
影响因子：
--
通讯作者：
Genotype to Phenotype Japan (G2P-Japan) Consortium
中科院分区：
文献类型：
--
作者：
Ferreira IATM;Kemp SA;Datir R;Saito A;Meng B;Rakshit P;Takaori-Kondo A;Kosugi Y;Uriu K;Kimura I;Shirakawa K;Abdullahi A;Agarwal A;Ozono S;Tokunaga K;Sato K;Gupta RK;CITIID-NIHR BioResource COVID-19 Collaboration, Indian SARS-CoV-2 Genomics Consortium;Genotype to Phenotype Japan (G2P-Japan) Consortium
2020年底，印度马哈拉施特拉邦出现了SARS-CoV-2 B.1.617变体。人们一直担心，在受体结合域发现的两个关键突变，L452R和E484Q，会对逃避中和抗体产生叠加效应。我们报道，携带L452R和E484Q的刺突在第一次或第二次接种后对BNT162b2 mRNA疫苗引发的抗体的敏感性略有降低。这种影响与L452R或E484Q单独引起的灵敏度损失的程度相似。这些数据表明L452R和E484Q对疫苗诱导的中和抗体的敏感性降低，但缺乏协同性的敏感性丧失。
The SARS-CoV-2 B.1.617 variant emerged in the Indian state of Maharashtra in late 2020. There have been fears that 2 key mutations seen in the receptor-binding domain, L452R and E484Q, would have additive effects on evasion of neutralizing antibodies. We report that spike bearing L452R and E484Q confers modestly reduced sensitivity to BNT162b2 mRNA vaccine-elicited antibodies following either first or second dose. The effect is similar in magnitude to the loss of sensitivity conferred by L452R or E484Q alone. These data demonstrate reduced sensitivity to vaccine-elicited neutralizing antibodies by L452R and E484Q but lack of synergistic loss of sensitivity.
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64.8
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