Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm.
Age in combination with gender is a valuable parameter in differential diagnosis of solid pseudopapillary tumors and pancreatic neuroendocrine neoplasm.
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DOI：
10.1186/s12902-022-01164-7
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发表时间：
2022-10-21
影响因子：
2.7
通讯作者：
Wei, Yushan
中科院分区：
文献类型：
--
作者：
Wu, Leshuang;Zou, Tianle;Shi, Dan;Cheng, Huan;Shahbaz, Muhammad;Umar, Muhammad;Li, Tianfeng;Zhang, Xianbin;Gong, Peng;Wei, Yushan
实性假乳头状瘤（SPT）和胰腺神经内分泌肿瘤（pNEN）的临床病理特征不同。因此，我们系统地研究了区分 SPT 和 pNEN 的临床病理学特征的表现。我们从监测、流行病学和最终结果计划中收集了病例。国际肿瘤学疾病分类第三版 (ICD-O-3) 肿瘤用于识别 pNEN 患者或 SPT 患者。为了确定年龄与性别相结合在区分 SPT 和 pNEN 方面的表现，开发了列线图，并通过受试者工作特征曲线和曲线下面积 (AUC) 评估该列线图的性能。在训练队列中，招募了 563 名 pNEN 患者和 30 名 SPT 患者。逻辑回归和受试者工作特征曲线表明年龄、性别、T 期、N 期和 M 期可以区分 SPT 和 pNEN。年龄、性别、T期、N期和M期的AUC分别为0.82、0.75、0.65、0.69和0.70。根据列线图，我们观察到年龄和性别的 AUC 显着高于 T 期、N 期和 M 期。本研究提出了一种无创列线图，可以帮助鉴别诊断 pNEN 和 SPT。这可能有助于临床医生区分 SPT 和 pNEN 并为患者选择合适的治疗方法。
The clinicopathological characteristics of solid pseudopapillary tumor (SPT) and pancreatic neuroendocrine neoplasm (pNEN) are different. We, therefore, systematically investigated the performance of the clinicopathological characteristics in distinguishing SPT from pNEN. We collected the cases from the Surveillance, Epidemiology, and End Results Program. The International Classification of Diseases for Oncology, third edition (ICD-O-3) for tumors was used to identify patients with pNEN or patients with SPT. To determine the performance of age in combination with gender in distinguishing SPT from pNEN, a nomogram was developed and the performance of this nomogram was evaluated by the receiver operating characteristic curve and the area under the curve (AUC). In the training cohort, 563 patients with pNENs and 30 patients with SPTs were recruited. The logistic regression and receiver operating characteristic curves suggest that age, gender, T-stage, N-stage, and M-stage could discriminate SPT and pNEN. The AUC of age, gender, T-stage, N-stage, and M-stage was 0.82, 0.75, 0.65, 0.69, and 0.70, respectively. Based on the nomogram, we observed that the AUC of age and gender is significantly high than that of the T-stage, N-stage, and M-stage. The present study proposes a non-invasive nomogram that could aid in the differential diagnosis of pNEN and SPT. This might help the clinicians to distinguish SPT from pNEN and choose the appropriate treatments for the patients.
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影响因子：
13.8
作者：
Xu Z;Wang L;Dai S;Chen M;Li F;Sun J;Luo F
通讯作者：
Luo F
影响因子：
--
作者：
Barral, Matthias;Soyer, Philippe;Boudiaf, Mourad
通讯作者：
Boudiaf, Mourad
影响因子：
5.5
作者：
Coleman, KM;Doherty, MC;Bigler, SA
通讯作者：
Bigler, SA
DOI：
10.1007/s00464-014-3508-8
发表时间：
2014-09-01
影响因子：
3.1
作者：
Law, Joanna K.;Stoita, Alina;Lennon, Anne Marie
通讯作者：
Lennon, Anne Marie
影响因子：
5.6
作者：
Notohara, K;Hamazaki, S;Okada, S
通讯作者：
Okada, S