Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease.
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease.
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DOI：
10.1038/s41583-019-0132-6
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发表时间：
2019-03
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Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully understand AD etiology and pathogenesis, but oxidative damage is a key component. Brain mostly uses glucose for energy, but in AD and amnestic mild cognitive impairment (aMCI) glucose metabolism is dramatically decreased, probably due, at least in part, to oxidative damage to enzymes involved in glycolysis, the tricarboxylic acid (TCA) cycle, and ATP biosynthesis. Consequently, ATP-requiring processes for cognitive function are impaired, and synaptic dysfunction and neuronal death result, with ensuing thinning of key brain areas. We summarize current research on the interplay and sequence of these processes and suggest potential pharmacological interventions to retard AD progression.
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DOI：
10.1038/nrneurol.2017.185
发表时间：
2018-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Arnold SE;Arvanitakis Z;Macauley-Rambach SL;Koenig AM;Wang HY;Ahima RS;Craft S;Gandy S;Buettner C;Stoeckel LE;Holtzman DM;Nathan DM
通讯作者：
Nathan DM
DOI：
10.3233/jad-122308
发表时间：
2013
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Claxton A;Baker LD;Wilkinson CW;Trittschuh EH;Chapman D;Watson GS;Cholerton B;Plymate SR;Arbuckle M;Craft S
通讯作者：
Craft S
影响因子：
2.5
作者：
Butterfield, DA;Reed, T;Sultana, R
通讯作者：
Sultana, R
影响因子：
4.8
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Choi, J;Levey, AI;Li, L
通讯作者：
Li, L
影响因子：
3.5
作者：
Branca, Caterina;Ferreira, Eric;Oddo, Salvatore
通讯作者：
Oddo, Salvatore