Pathogenesis of food allergy in the pediatric patient.

Pathogenesis of food allergy in the pediatric patient.
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DOI:
10.1007/s11882-012-0296-x
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发表时间:
2012-12
影响因子:
5.5
通讯作者:
Vickery, Brian P.
Vickery, Brian P.
中科院分区:
医学2区
文献类型:
--
作者:
Chin, Stacy;Vickery, Brian P.

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在美国和其他发达国家,食物过敏在儿科人群中日益流行,对健康相关的生活质量产生重大影响。因此,正在进行大量的努力来阐明口腔粘膜耐受的机制,并更好地定义与宿主和过敏原暴露相关的因素,这些因素有助于导致致敏和临床食物过敏的异常免疫应答。虽然需要更多的研究,最终制定有针对性的治疗和预防策略,这篇综述强调了我们目前对IgE介导的食物过敏的发病机制的理解。
In the US and other developed countries, food allergy is a growing epidemic in pediatric populations with a substantial impact on health-related quality of life. As such, there are great efforts underway to unravel the mechanisms of oral mucosal tolerance and to better define the factors related to host and allergen exposure that contribute to the aberrant immune response leading to sensitization and clinical food allergy. Although more research is needed to eventually develop targeted treatment and prevention strategies, this review highlights our current understanding of the pathogenesis of IgE-mediated food allergy.
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