Tumefactive demyelination in a patient with human immunodeficiency virus.
Tumefactive demyelination in a patient with human immunodeficiency virus.
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DOI：
10.1007/s13365-013-0165-y
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发表时间：
2013-06
影响因子：
3.2
通讯作者：
Ances, Beau M.
中科院分区：
文献类型：
--
作者：
Solomon, Isaac H.;Perrin, Richard J.;Clifford, David B.;Ances, Beau M.
大脑是艾滋病毒感染的常见目标，并可能通过病毒的直接和间接影响而受损。白色改变包括HIV白质脑病和空泡性脊髓病是常见的（Gray and Lescs 1993）。对多种病原体[巨细胞病毒（CMV）、结核病、梅毒、隐球菌、弓形虫、JC病毒（JCV）等]的易感性增加在极少数情况下，HIV感染与肿胀性脱髓鞘（TD）有关，TD是一种不同于多发性硬化（MS）或急性播散性脑脊髓炎（ADEM）的疾病。放射学上，TD由不完整的边缘增强“肿瘤样”病变组成（Ball 2004; Saravanan和Turnbull 2009; Uriel等人2010）。我们目前的神经系统，放射学和病理结果与一年的后续行动，从一个病人谁提出的神经影像学结果与TD一致，谁是伴随诊断为艾滋病毒。
The brain is a common target of HIV infection, and may be damaged through direct and indirect effects of the virus. White matter changes including HIV leukoencephalopathy and vacuolar myelopathy are often seen (Gray and Lescs 1993). Increased susceptibility to a wide variety of pathogens [cytomegalovirus (CMV), tuberculosis, syphilis, cryptococcus, toxoplasma, JC virus (JCV), etc.] and neoplastic processes (primary CNS lymphoma) occurs when CD4+ cell counts are greatly diminished.In rare cases, HIV infection has been associated with tumefactive demyelination (TD), a disorder distinct from either multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM). Radiologically, TD consists of an incomplete rim enhancing “tumor-like” lesion (Ball 2004; Saravanan and Turnbull 2009; Uriel et al. 2010). We present the neurologic, radiologic, and pathologic findings with one year of follow-up from a patient who presented with neuroimaging findings consistent with TD and who was concomitantly diagnosed with HIV.
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影响因子：
2.6
作者：
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通讯作者：
Turnbull, I. W.
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