Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring.
Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring.
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母体血清中多环芳烃的水平与后代神经管缺陷的风险
DOI：
10.1021/es503990v
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发表时间：
2015-01-06
影响因子：
11.4
通讯作者：
Finnell, Richard H.
中科院分区：
文献类型：
--
作者：
Wang, Bin;Jin, Lei;Ren, Aiguo;Yuan, Yue;Liu, Jufen;Li, Zhiwen;Zhang, Le;Yi, Deqing;Wang, Lin-lin;Zhang, Yali;Wang, Xilong;Tao, Shu;Finnell, Richard H.
多环芳烃（PAHs）是一种普遍存在的环境污染物，已被报道是人类神经管缺陷（NTDs）的危险因素。我们采用病例对照研究设计，调查了母亲血清中PAH浓度与后代NTD风险之间的关系，并探讨了PAH浓度与家庭能源使用特征和生活方式之间的联系。在中国北方招募了117名患有NTD的孕妇（病例）和121名分娩健康婴儿的妇女（对照）。在妊娠终止或分娩时采集母体血液样本。采用气相色谱-质谱联用仪测定了27种多环芳烃。13个单独的多环芳烃检测到的浓度显着高于对照组的情况下。即使调整了潜在的协变量，也观察到大多数单个多环芳烃浓度与总NTD或亚型风险之间存在明确的剂量-反应关系。高分子量多环芳烃（H-PAHs）的风险高于低分子量多环芳烃（L-PAHs）。PAH浓度与室内生活方式和能源使用特征之间没有关联。得出的结论是，母亲暴露于多环芳烃与NTDs的风险增加，和H-PAHs总体上构成了NTDs的风险高于L-PAHs。
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, and have been reported to be a risk factor for human neural tube defects (NTDs). We investigated the relationship between PAH concentrations in maternal serum and NTD risk in offspring using a case-control study design, and explored the link between PAH concentrations to household energy usage characteristics and life styles. One hundred and seventeen women who had NTD-affected pregnancies (cases) and 121 women who delivered healthy infants (controls) were recruited in Northern China. Maternal blood samples were collected at pregnancy termination or at delivery. Twenty-seven PAHs were measured by gas chromatography–mass spectrometry. The concentrations of 13 individual PAHs detected were significantly higher in the cases than in the controls. Clear dose–response relationships between concentrations of most individual PAHs and the risk of total NTDs or subtypes were observed, even when potential covariates were adjusted for. High-molecular-weight PAHs (H-PAHs) showed higher risk than low-molecular-weight PAHs (L-PAHs). No associations between PAH concentrations and indoor life styles and energy usage characteristics were observed. It was concluded that maternal exposure to PAHs was associated with an increased risk of NTDs, and H-PAHs overall posed a higher risk for NTDs than L-PAHs.
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影响因子：
11.4
作者：
Shen, Guofeng;Tao, Shu;Wang, Wei;Yang, Yifeng;Ding, Junnan;Xue, Miao;Min, Yujia;Zhu, Chen;Shen, Huizhong;Li, Wei;Wang, Bin;Wang, Rong;Wang, Wentao;Wang, Xilong;Russell, Armistead G.
通讯作者：
Russell, Armistead G.
影响因子：
11.4
作者：
Deng, Qifei;Dai, Xiayun;Wu, Tangchun
通讯作者：
Wu, Tangchun
影响因子：
7.1
作者：
James, SJ;Cutler, P;Neubrander, JA
通讯作者：
Neubrander, JA
影响因子：
6
作者：
Alomirah, Husam;Al-Zenki, Sameer;Kannan, Kurunthachalam
通讯作者：
Kannan, Kurunthachalam
影响因子：
8.8
作者：
Rylander, L;Nilsson-Ehle, P;Hagmar, L
通讯作者：
Hagmar, L