Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms.
Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms.
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DOI：
10.1080/01635581.2011.553021
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Makar KW
中科院分区：
文献类型：
--
作者：
Burnett-Hartman AN;Newcomb PA;Mandelson MT;Adams SV;Wernli KJ;Shadman M;Wurscher MA;Makar KW
我们确定了烧焦肉类消费、吸烟、微粒体环氧化物水解酶 (mEH) 多态性 [rs1051740 和 rs2234922] 以及结直肠腺瘤和增生性息肉 (HP) 之间的关联，并探索了基因-环境相互作用。招募了患有结直肠腺瘤 (n = 519)、HP (n = 691) 或同时患有两种类型息肉 (n = 227) 和无息肉对照 (n = 772) 的男性和女性，这些对照在 2004 年 12 月至 9 月 7 日期间接受了结肠镜检查。参与者完成电话采访并提供口腔细胞样本；使用 Taqman 检测完成 mEH 的基因分型。我们进行了多项回归并计算了奇数比 (OR) 和 95% 置信区间。使用 Wald 卡方检验评估相互作用。每周食用超过 3 份烧焦肉与远端 HP 相关（OR=2.0，1.2-3.4），但与腺瘤或任何类型的近端息肉无关。大量吸烟（≥22包年）与结直肠腺瘤（OR=1.7，95% CI 1.2-2.4）、HP（OR=2.4，95% CI 1.7-3.3）风险增加相关，并且两种类型（OR=2.8，95% CI 1.8-4.3）与远端息肉的相关性最强。 mEH 基因型与结直肠息肉之间没有关联，也没有发现任何统计学上显着的基因-环境相互作用。未来对 BaP 暴露和结直肠肿瘤的研究应分析关联是否取决于解剖位置。
We determined the association between charred meat consumption, cigarette smoking, microsomal epoxide hydrolase (mEH) polymorphisms [rs1051740 and rs2234922], and colorectal adenomas and hyperplastic polyps (HPs) and explored gene-environment interactions. Men and women with colorectal adenomas (n=519), HPs (n=691), or concurrently with both types of polyps (n=227) and polyp-free controls (n=772) receiving a colonoscopy from 12/04-9/07 were recruited. Participants completed telephone interviews and provided buccal cell samples; genotyping of mEH was completed using Taqman assays. We conducted polytomous regression and calculated odd ratios (OR) and 95% confidence intervals. Interactions were evaluated using Wald chi-square tests. Consumption of >3 servings of charred meat per week was associated with distal HPs (OR=2.0, 1.2–3.4) but not adenomas nor either type of proximal polyp. Heavy cigarette smoking (≥22 pack-years) was associated with an increased risk for colorectal adenomas (OR=1.7, 95% CI 1.2–2.4), HPs (OR=2.4, 95% CI 1.7–3.3), and both types (OR=2.8, 95% CI 1.8–4.3) with the strongest association for distal polyps. There was no association between mEH genotype and colorectal polyps, nor were any statistically significant gene-environment interactions identified. Future investigation of BaP exposure and colorectal neoplasia should analyze whether associations are dependent upon anatomic location.
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影响因子：
4.7
作者：
Goode, Ellen L.;Potter, John D.;Bigler, Jeannette
通讯作者：
Bigler, Jeannette
影响因子：
1.8
作者：
CAVALIERI, EL;ROGAN, EG
通讯作者：
ROGAN, EG
影响因子：
0.9
作者：
Mayo, Oliver
通讯作者：
Mayo, Oliver
影响因子：
3.9
作者：
Jass, JR
通讯作者：
Jass, JR
DOI：
10.1006/bbrc.2000.4161
发表时间：
2001-02-23
影响因子：
3.1
作者：
Fang, AH;Smith, WA;Gupta, RC
通讯作者：
Gupta, RC