Neuroscience of Compulsive Eating Behavior.

Neuroscience of Compulsive Eating Behavior.
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强迫饮食行为的神经科学。

DOI:
10.3389/fnins.2017.00469
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发表时间:
2017
影响因子:
4.3
通讯作者:
Cottone P
Cottone P
中科院分区:
医学2区
文献类型:
--
作者:
Moore CF;Sabino V;Koob GF;Cottone P

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在三个功能领域的背景下,人们提出了对饮食病理形式强迫性的系统表征:(1)习惯性暴饮暴食; (2)暴饮暴食以缓解负面情绪状态; (3)不顾不良后果而暴饮暴食。在这篇综述中,我们提供了支持这一假设的证据,并通过其潜在的神经心理生物学过程区分了强迫性饮食的神经回路和神经化学介质的新生领域。更好地了解导致强迫性饮食行为的神经生物学机制可以改善对病理性饮食障碍的行为和药物干预。
A systematic characterization of compulsivity in pathological forms of eating has been proposed in the context of three functional domains: (1) habitual overeating; (2) overeating to relieve a negative emotional state; and (3) overeating despite aversive consequences. In this review, we provide evidence supporting this hypothesis and we differentiate the nascent field of neurocircuits and neurochemical mediators of compulsive eating through their underlying neuropsychobiological processes. A better understanding of the neurobiological mechanisms that lead to compulsive eating behavior can improve behavioral and pharmacological intervention for disorders of pathological eating.
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