Impact of ambient air pollution on the differential white blood cell count in patients with chronic pulmonary disease.
Impact of ambient air pollution on the differential white blood cell count in patients with chronic pulmonary disease.
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DOI：
10.3109/08958370903207274
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发表时间：
2010-02
影响因子：
2.1
通讯作者：
Peters A
中科院分区：
文献类型：
--
作者：
Brüske I;Hampel R;Socher MM;Rückerl R;Schneider A;Heinrich J;Oberdörster G;Wichmann HE;Peters A
流行病学研究报告了颗粒物空气污染与肺部疾病死亡率增加之间的关系。研究暴露于周围气体和颗粒物空气污染是否会导致慢性肺病患者白细胞分类计数的改变，如慢性支气管炎、慢性阻塞性肺疾病和哮喘。在东德埃尔福特进行了一项前瞻性小组研究，对38名患有慢性肺部疾病的男性进行了12次重复差异白细胞计数。获取了每小时颗粒物和气态空气污染物以及气象数据。随机截距调整趋势、气象、工作日和其他风险变量的混合模型被使用。在这项探索性分析中，我们发现，随着大多数气体和颗粒物污染物的增加，多形核白细胞的数量立即减少。与所有气体污染物相关的淋巴细胞在24小时内增加，但对颗粒性空气污染没有影响。单核细胞表现出与超细颗粒和一氧化氮相关的增加。起效时间有两个高峰，一个是停血前0~23h，第二个高峰是48~71h。颗粒物和气态空气污染的增加与慢性肺病患者白细胞分类计数的多重变化有关。
Epidemiologic studies report associations between particulate air pollution and increased mortality from pulmonary diseases.To examine whether the exposure to ambient gaseous and particulate air pollution leads to an alteration of the differential white blood cell count in patients with chronic pulmonary diseases like chronic bronchitis, chronic obstructive pulmonary disease, and asthma. A prospective panel study was conducted in Erfurt, Eastern Germany, with 12 repeated differential white blood cell counts in 38 males with chronic pulmonary diseases. Hourly particulate and gaseous air pollutants and meteorological data were acquired. Mixed models with a random intercept adjusting for trend, meteorology, weekday, and other risk variables were used. In this explorative analysis we found an immediate decrease of polymorphonuclear leukocytes in response to an increase of most gaseous and particulate pollutants. Lymphocytes increased within 24 hours in association with all gaseous pollutants but showed no effect in regard to particulate air pollution. Monocytes showed an increase associated with ultrafine particles, and nitrogen monoxide. The effect had two peaks in time, one 0-23 hours before blood withdrawal and a second one with a time lag of 48-71 hours. The increase of particulate and gaseous air pollution was associated with multiple changes in the differential white blood cell count in patients with chronic pulmonary diseases.
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影响因子：
10.4
作者：
Rückerl R;Greven S;Ljungman P;Aalto P;Antoniades C;Bellander T;Berglind N;Chrysohoou C;Forastiere F;Jacquemin B;von Klot S;Koenig W;Küchenhoff H;Lanki T;Pekkanen J;Perucci CA;Schneider A;Sunyer J;Peters A;AIRGENE Study Group
通讯作者：
AIRGENE Study Group
影响因子：
32.4
作者：
Romano, M;Sironi, M;Mantovani, A
通讯作者：
Mantovani, A
影响因子：
9.8
作者：
Cyrys, J;Stölzel, M;Wichmann, HE
通讯作者：
Wichmann, HE
影响因子：
9.6
作者：
van Eeden, SF;Kitagawa, Y;Hogg, JC
通讯作者：
Hogg, JC
DOI：
10.1165/ajrcmb.27.1.4787
发表时间：
2002-07-01
影响因子：
6.4
作者：
Fujii, T;Hayashi, S;van Eeden, SF
通讯作者：
van Eeden, SF