Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors.
Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors.
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DOI：
10.1289/ehp.10021
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发表时间：
2007-07
影响因子：
10.4
通讯作者：
AIRGENE Study Group
中科院分区：
文献类型：
--
作者：
Rückerl R;Greven S;Ljungman P;Aalto P;Antoniades C;Bellander T;Berglind N;Chrysohoou C;Forastiere F;Jacquemin B;von Klot S;Koenig W;Küchenhoff H;Lanki T;Pekkanen J;Perucci CA;Schneider A;Sunyer J;Peters A;AIRGENE Study Group
许多研究发现，环境空气污染与心血管疾病恶化有关。鉴于先前的研究结果，我们假设颗粒空气污染可能会诱导心肌梗死（MI）幸存者的全身炎症，导致对环境颗粒浓度升高的脆弱性增加。2003年5月至2004年7月在欧洲6个城市对1,003名心肌梗死幸存者进行了前瞻性纵向研究。我们比较了白细胞介素6（IL-6），纤维蛋白原和C-反应蛋白（CRP）的重复测量与同期空气污染水平。我们收集了每个城市中心监测点的颗粒物数浓度（PNC）、< 10 μm（PM10）和< 2.5 μm（PM2.5）的颗粒物（PM）质量浓度、气态污染物和气象数据的小时数据。城市特定的混杂模型分别建立每个血液标志物，调整气象学和时变和时不变的协变量。采用混合效应模型对数据进行分析。汇总结果显示，当PNC浓度在采血前12-17小时升高时，IL-6升高[几何平均值的百分比变化，2.7; 95%置信区间（CI），1.0-4.6]。5天累积暴露于PM10与纤维蛋白原浓度升高相关（算术平均值的百分比变化，0.6; 95% CI，0.1-1.1）。吸烟者、糖尿病患者和心力衰竭患者的结果保持稳定。未发现与CRP存在一致的相关性。结果表明，立即响应PNC的IL-6水平，可能导致急性期蛋白的生产，如纤维蛋白原水平增加。这可能提供了空气污染和不良心脏事件之间的联系。
Numerous studies have found that ambient air pollution has been associated with cardiovascular disease exacerbation. Given previous findings, we hypothesized that particulate air pollution might induce systemic inflammation in myocardial infarction (MI) survivors, contributing to an increased vulnerability to elevated concentrations of ambient particles. A prospective longitudinal study of 1,003 MI survivors was performed in six European cities between May 2003 and July 2004. We compared repeated measurements of interleukin 6 (IL-6), fibrinogen, and C-reactive protein (CRP) with concurrent levels of air pollution. We collected hourly data on particle number concentrations (PNC), mass concentrations of particulate matter (PM) < 10 μm (PM10) and < 2.5 μm (PM2.5), gaseous pollutants, and meteorologic data at central monitoring sites in each city. City-specific confounder models were built for each blood marker separately, adjusting for meteorology and time-varying and time-invariant covariates. Data were analyzed with mixed-effects models. Pooled results show an increase in IL-6 when concentrations of PNC were elevated 12–17 hr before blood withdrawal [percent change of geometric mean, 2.7; 95% confidence interval (CI), 1.0–4.6]. Five day cumulative exposure to PM10 was associated with increased fibrinogen concentrations (percent change of arithmetic mean, 0.6; 95% CI, 0.1–1.1). Results remained stable for smokers, diabetics, and patients with heart failure. No consistent associations were found for CRP. Results indicate an immediate response to PNC on the IL-6 level, possibly leading to the production of acute-phase proteins, as seen in increased fibrinogen levels. This might provide a link between air pollution and adverse cardiac events.
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影响因子：
5.9
作者：
Harris, TB;Ferrucci, L;Wallace, R
通讯作者：
Wallace, R
DOI：
10.1164/rccm.200412-1726oc
发表时间：
2005-12-15
影响因子：
24.7
作者：
Forastiere, F;Stafoggia, M;Perucci, CA
通讯作者：
Perucci, CA
影响因子：
105.7
作者：
Danesh, J;Whincup, P;Pepys, MB
通讯作者：
Pepys, MB
影响因子：
37.8
作者：
Khandoga, A;Stampfl, A;Krombach, F
通讯作者：
Krombach, F
影响因子：
8.3
作者：
Goldberg, MS;Burnett, RT;Brook, JR
通讯作者：
Brook, JR