T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance.
T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance.
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T 细胞消耗纳米粒子通过减少活化的 T 细胞和调节 Treg/Th17 平衡来改善骨质流失
DOI：
10.1016/j.bioactmat.2021.02.034
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发表时间：
2021-10
影响因子：
18.9
通讯作者：
Jin Y
中科院分区：
文献类型：
--
作者：
Yang X;Zhou F;Yuan P;Dou G;Liu X;Liu S;Wang X;Jin R;Dong Y;Zhou J;Lv Y;Deng Z;Liu S;Chen X;Han Y;Jin Y
Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women. Under chronic inflammatory conditions caused by estrogen deficiency, activated T cells contribute to elevated levels of proinflammatory cytokines, impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells (BMMSCs), and disturbed regulatory T cell (Treg)/Th17 cell balance. However, therapeutic strategies that re-establish immune homeostasis in this disorder have not been well developed. Here, we produced T cell-depleting nanoparticles (TDNs) that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized (OVX) mice. TDNs consist of monocyte chemotactic protein-1 (MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand (FasL) as the corona. We showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo. Apoptotic signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state, further attenuating the osteogenic deficiency of BMMSCs and the osteopenia phenotype. Mechanistically, we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles (ApoEVs), which promoted macrophage transformation towards the M2 phenotype. These findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders. Schematic illustration of TDNs and their therapeutic effects on osteoporosis through inducing T cell apoptosis and regulating Treg/Th17 balance. A delicate nanoparticle was prepared which can induce the apoptosis of activated T cells. The T cell-depleting nanoparticles establish an immune tolerance microenvironment and ameliorate bone loss in OVX mice. T cell-derived apoptotic extracellular vesicles participated in the amelioration of osteopenia.
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影响因子：
5.8
作者：
Bae, Joonho;Park, Jin Woo
通讯作者：
Park, Jin Woo
影响因子：
3.9
作者：
Carcao, Manuel D.
通讯作者：
Carcao, Manuel D.
DOI：
10.1016/j.ecl.2016.09.009
发表时间：
2017-03-01
影响因子：
4.5
作者：
Khan, Moira;Cheung, Angela M.;Khan, Aliya A.
通讯作者：
Khan, Aliya A.
影响因子：
3.6
作者：
Liu, H.;Liu, L.;Li, F.
通讯作者：
Li, F.
影响因子：
2.5
作者：
Dar HY;Shukla P;Mishra PK;Anupam R;Mondal RK;Tomar GB;Sharma V;Srivastava RK
通讯作者：
Srivastava RK