Synthesis of Small Lipid Nanoparticles Using an Inkjet Mixing System Aiming to Reduce Drug Loss
Synthesis of Small Lipid Nanoparticles Using an Inkjet Mixing System Aiming to Reduce Drug Loss
复制标题
使用喷墨混合系统合成小脂质纳米颗粒，旨在减少药物损失
DOI：
10.1002/ceat.201900041
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发表时间：
2019
影响因子：
2.1
通讯作者：
K. Mae
中科院分区：
文献类型：
--
作者：
K. Inohara;Shusaku Asano;T. Maki;K. Mae
研究了喷墨混合系统，通过混合脂质乙醇和盐水溶液来合成脂质纳米颗粒（LNP）。该系统用于帮助最大限度地减少药物损失。液滴的快速混合能够合成小型 LNP，同时减少含有药物的过量盐水溶液。该系统还具有最少使用试剂的特点。与之前使用微混合器的研究相比，使用更少的盐溶液成功合成了小型 LNP。高相对速度和适中的冲击参数值对于成功混合是必要的。较快的液滴应该与较慢的液滴的上部或水平面碰撞以促进混合。聚结液滴的水平旋转比垂直旋转更受青睐。
An inkjet mixing system was investigated to synthesize lipid nanoparticles (LNPs) by mixing lipid ethanol and aqueous saline solutions. The system was employed to help minimize drug loss. The quick mixing of the droplets enabled the synthesis of small LNPs with reducing the excess amount of saline solution which would contain drugs. The system also features minimal usage of reagent. Small LNPs were successfully synthesized with less saline solution than previous studies using micromixers. A high relative velocity and moderate values of the impact parameter were necessary for successful mixing. A faster droplet should have collided with the upper or horizontal level of a slower droplet to promote mixing. A horizontal spin of the coalesced droplets was favored rather than a vertical spin.
影响因子：
10.8
作者：
Gupta MK;Meng F;Johnson BN;Kong YL;Tian L;Yeh YW;Masters N;Singamaneni S;McAlpine MC
通讯作者：
McAlpine MC