A pair of transmembrane receptors essential for the retention and pigmentation of hair.
A pair of transmembrane receptors essential for the retention and pigmentation of hair.
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DOI：
10.1002/dvg.22039
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发表时间：
2012-11
期刊：
影响因子：
1.5
通讯作者：
Brissette, Janice L.
中科院分区：
文献类型：
--
作者：
Han, Rong;Beppu, Hideyuki;Lee, Yun-Kyoung;Georgopoulos, Katia;Larue, Lionel;Li, En;Weiner, Lorin;Brissette, Janice L.
Hair follicles are simple, accessible models for many developmental processes. Here, using mutant mice, we show that Bmpr2, a known receptor for bone morphogenetic proteins (Bmps), and Acvr2a, a known receptor for Bmps and activins, are individually redundant but together essential for multiple follicular traits. When Bmpr2/Acvr2a function is reduced in cutaneous epithelium, hair follicles undergo rapid cycles of hair generation and loss. Alopecia results from a failure to terminate hair development properly, as hair clubs never form, and follicular retraction is slowed. Hair regeneration is rapid due to premature activation of new hair-production programs. Hair shafts differentiate aberrantly due to impaired arrest of medullary-cell proliferation. When Bmpr2/Acvr2a function is reduced in melanocytes, gray hair develops, as melanosomes differentiate but fail to grow, resulting in organelle miniaturization. We conclude that Bmpr2 and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.
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影响因子：
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通讯作者：
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