Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
Characterization of SARS-CoV-2 different variants and related morbidity and mortality: a systematic review.
复制标题
DOI：
10.1186/s40001-021-00524-8
复制
发表时间：
2021-06-08
影响因子：
4.2
通讯作者：
Shayesteh Jahanfar
中科院分区：
文献类型：
--
作者：
SeyedAlinaghi S;Mirzapour P;Dadras O;Pashaei Z;Karimi A;MohsseniPour M;Soleymanzadeh M;Barzegary A;Afsahi AM;Vahedi F;Shamsabadi A;Behnezhad F;Saeidi S;Mehraeen E;Shayesteh Jahanfar
2019年12月，2019年冠状病毒病（SARS-CoV-2）在中国武汉开始了其毁灭性的全球大流行轨迹。从那时起，已经确定了SARS-CoV-2的几种变体。在本综述中，我们的目的是表征不同的变异的SARS-CoV-2，并探讨相关的发病率和死亡率。通过使用在线数据库（包括Scopus、PubMed、Web of Science和Science Direct）中的关键词进行系统检索，对与SARS-CoV-2不同变体相关的现有证据以及相关发病率和死亡率进行了系统综述;我们检索了2019年12月至2020年9月期间以英文发表的所有相关论文和报告。 对已识别文章的综述显示了三种主要的基因组变异，包括A型、B型和C型。我们还鉴定了包括S、V和G的三个分支。研究表明，Nsp 12和S蛋白中的C14408 T和A23403 G变异是全球最突出的变异，会导致危及生命的突变，尖峰D 614 G氨基酸变异自2019年12月以来已成为最常见的变异。从古吉拉特SARS-CoV-2基因组中发现的错义突变C28854 T，核衣壳（N）基因中的有害突变与患者的死亡率显著相关。另一个重要的有害变体（G25563 T）在患者中发现，位于Orf 3a，并在病毒发病机制中具有潜在作用。总体而言，研究人员发现了几种SARS-CoV-2变异体，这些变异体改变了临床表现，增加了COVID-19的传播性、发病率和死亡率。在目前的做法和干预措施中应考虑到这一点，以防治这一流行病并预防相关的发病率和死亡率。
Coronavirus Disease-2019 (SARS-CoV-2) started its devastating trajectory into a global pandemic in Wuhan, China, in December 2019. Ever since, several variants of SARS-CoV-2 have been identified. In the present review, we aimed to characterize the different variants of SARS-CoV-2 and explore the related morbidity and mortality. A systematic review including the current evidence related to different variants of SARS-CoV-2 and the related morbidity and mortality was conducted through a systematic search utilizing the keywords in the online databases including Scopus, PubMed, Web of Science, and Science Direct; we retrieved all related papers and reports published in English from December 2019 to September 2020. A review of identified articles has shown three main genomic variants, including type A, type B, and type C. we also identified three clades including S, V, and G. Studies have demonstrated that the C14408T and A23403G alterations in the Nsp12 and S proteins are the most prominent alterations in the world, leading to life-threatening mutations.The spike D614G amino acid change has become the most common variant since December 2019. From missense mutations found from Gujarat SARS-CoV-2 genomes, C28854T, deleterious mutation in the nucleocapsid (N) gene was significantly associated with patients' mortality. The other significant deleterious variant (G25563T) is found in patients located in Orf3a and has a potential role in viral pathogenesis. Overall, researchers identified several SARS-CoV-2 variants changing clinical manifestations and increasing the transmissibility, morbidity, and mortality of COVID-19. This should be considered in current practice and interventions to combat the pandemic and prevent related morbidity and mortality.
登录
查看更多内容
影响因子：
4.9
作者：
Forni D;Cagliani R;Pontremoli C;Mozzi A;Pozzoli U;Clerici M;Sironi M
通讯作者：
Sironi M
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
3.7
作者：
De Vito A;Fiore V;Princic E;Geremia N;Panu Napodano CM;Muredda AA;Maida I;Madeddu G;Babudieri S
通讯作者：
Babudieri S
影响因子：
64.8
作者：
Gordon, David E.;Jang, Gwendolyn M.;Krogan, Nevan J.
通讯作者：
Krogan, Nevan J.
DOI：
10.1126/science.abh2644
发表时间：
2021-05-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Faria NR;Mellan TA;Whittaker C;Claro IM;Candido DDS;Mishra S;Crispim MAE;Sales FCS;Hawryluk I;McCrone JT;Hulswit RJG;Franco LAM;Ramundo MS;de Jesus JG;Andrade PS;Coletti TM;Ferreira GM;Silva CAM;Manuli ER;Pereira RHM;Peixoto PS;Kraemer MUG;Gaburo N Jr;Camilo CDC;Hoeltgebaum H;Souza WM;Rocha EC;de Souza LM;de Pinho MC;Araujo LJT;Malta FSV;de Lima AB;Silva JDP;Zauli DAG;Ferreira ACS;Schnekenberg RP;Laydon DJ;Walker PGT;Schlüter HM;Dos Santos ALP;Vidal MS;Del Caro VS;Filho RMF;Dos Santos HM;Aguiar RS;Proença-Modena JL;Nelson B;Hay JA;Monod M;Miscouridou X;Coupland H;Sonabend R;Vollmer M;Gandy A;Prete CA Jr;Nascimento VH;Suchard MA;Bowden TA;Pond SLK;Wu CH;Ratmann O;Ferguson NM;Dye C;Loman NJ;Lemey P;Rambaut A;Fraiji NA;Carvalho MDPSS;Pybus OG;Flaxman S;Bhatt S;Sabino EC
通讯作者：
Sabino EC