How receptor diffusion influences gradient sensing
How receptor diffusion influences gradient sensing
复制标题
受体扩散如何影响梯度传感
DOI：
10.1098/rsif.2014.1097
复制
发表时间：
2015
影响因子：
3.9
通讯作者：
Geoffrey J. Goodhill
中科院分区：
文献类型：
--
作者：
Huyen Nguyen;Peter Dayan;Geoffrey J. Goodhill
趋化性，或化学梯度中的定向运动，对各种生物过程至关重要。许多真核细胞执行空间感知，即它们通过比较化学感觉受体跨膜结合的空间差异来检测梯度。在许多空间感知的理论模型中，为了简单起见，都假定相关的感受器不运动。然而，在现实中，受体经历了不同的扩散模式，在这些细胞转化为外部梯度所需的时间内，可以穿越相当长的距离。这对空间感知的精确度设置了物理限制，我们使用受体在膜上自由扩散的模型来探索这一点。我们发现，结合和非结合事件中携带的Fisher信息随着受体的扩散常数单调减少。
Chemotaxis, or directed motion in chemical gradients, is critical for various biological processes. Many eukaryotic cells perform spatial sensing, i.e. they detect gradients by comparing spatial differences in binding occupancy of chemosensory receptors across their membrane. In many theoretical models of spatial sensing, it is assumed, for the sake of simplicity, that the receptors concerned do not move. However, in reality, receptors undergo diverse modes of diffusion, and can traverse considerable distances in the time it takes such cells to turn in an external gradient. This sets a physical limit on the accuracy of spatial sensing, which we explore using a model in which receptors diffuse freely over the membrane. We find that the Fisher information carried in binding and unbinding events decreases monotonically with the diffusion constant of the receptors.
影响因子：
8.6
作者：
Hu B;Chen W;Rappel WJ;Levine H
通讯作者：
Levine H
DOI：
10.1073/pnas.0504321102
发表时间：
2005-07-19
影响因子：
11.1
作者：
Bialek, W;Setayeshgar, S
通讯作者：
Setayeshgar, S