Measurement of respiratory rate using wearable devices and applications to COVID-19 detection.
Measurement of respiratory rate using wearable devices and applications to COVID-19 detection.
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DOI：
10.1038/s41746-021-00493-6
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发表时间：
2021-09-15
影响因子：
15.2
通讯作者：
Niehaus L
中科院分区：
文献类型：
--
作者：
Natarajan A;Su HW;Heneghan C;Blunt L;O'Connor C;Niehaus L
我们展示了心率支持的可穿戴设备可以用来测量呼吸频率。呼吸调节心率，以与呼吸频率相等的频率在心率变异性中产生多余的能量，这种现象被称为呼吸性窦性心律失常。我们将这一分量从心跳间隔时间序列的功率谱密度中分离出来，并表明由此估计的呼吸频率与从睡眠研究中获得的验证数据非常一致（均方根误差= 0.648 min - 1，平均绝对误差= 0.46 min - 1，平均绝对百分比误差= 3%）。我们使用这种呼吸频率算法来阐明两种潜在的应用(a)理解夜间呼吸频率随年龄和性别的分布，以及(b)检查由于呼吸道感染（如COVID-19）导致的纵向夜间呼吸频率的变化。健康成人90%的呼吸速率值在11.8 - 19.2 min - 1范围内，平均值为15.4 min - 1。呼吸频率随着夜间心率的增加而增加。它也随BMI的变化而变化，在25 kg/m2时达到最小值，随着BMI的高低而增加。呼吸频率随年龄增长略有下降，50岁以下女性呼吸频率高于男性，此后男女呼吸频率无显著差异。在14天内，女性（男性）的变异系数90%的范围从20 - 24岁的2.3 - 9.2%（2.3 - 9.5%）到65 - 69岁的2.5 - 16.8%（2.7 - 21.7%）不等。我们发现，被诊断为COVID-19的受试者呼吸频率通常升高。在从D - 1到D+5的7天窗口中（其中D0是症状首次出现的日期，对于有症状的个体，无症状病例的检测日期），我们发现36.4%（23.7%）的有症状（无症状）个体至少有一次呼吸频率测量比正常频率高3分钟−1。
We show that heart rate enabled wearable devices can be used to measure respiratory rate. Respiration modulates the heart rate creating excess power in the heart rate variability at a frequency equal to the respiratory rate, a phenomenon known as respiratory sinus arrhythmia. We isolate this component from the power spectral density of the heart beat interval time series, and show that the respiratory rate thus estimated is in good agreement with a validation dataset acquired from sleep studies (root mean squared error = 0.648 min−1, mean absolute error = 0.46 min−1, mean absolute percentage error = 3%). We use this respiratory rate algorithm to illuminate two potential applications (a) understanding the distribution of nocturnal respiratory rate as a function of age and sex, and (b) examining changes in longitudinal nocturnal respiratory rate due to a respiratory infection such as COVID-19. 90% of respiratory rate values for healthy adults fall within the range 11.8−19.2 min−1 with a mean value of 15.4 min−1. Respiratory rate is shown to increase with nocturnal heart rate. It also varies with BMI, reaching a minimum at 25 kg/m2, and increasing for lower and higher BMI. The respiratory rate decreases slightly with age and is higher in females compared to males for age <50 years, with no difference between females and males thereafter. The 90% range for the coefficient of variation in a 14 day period for females (males) varies from 2.3–9.2% (2.3−9.5%) for ages 20−24 yr, to 2.5−16.8% (2.7−21.7%) for ages 65−69 yr. We show that respiratory rate is often elevated in subjects diagnosed with COVID-19. In a 7 day window from D−1 to D+5 (where D0 is the date when symptoms first present, for symptomatic individuals, and the test date for asymptomatic cases), we find that 36.4% (23.7%) of symptomatic (asymptomatic) individuals had at least one measurement of respiratory rate 3 min−1 higher than the regular rate.
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影响因子：
2.3
作者：
Behan, Mary;Wenninger, Julie M.
通讯作者：
Wenninger, Julie M.
影响因子：
17.6
作者：
Charlton PH;Birrenkott DA;Bonnici T;Pimentel MAF;Johnson AEW;Alastruey J;Tarassenko L;Watkinson PJ;Beale R;Clifton DA
通讯作者：
Clifton DA
DOI：
10.1183/20734735.000318
发表时间：
2018-06
期刊：
Breathe (Sheffield, England)
影响因子：
--
作者：
LoMauro A;Aliverti A
通讯作者：
Aliverti A
影响因子：
2.9
作者：
de Zambotti, Massimiliano;Baker, Fiona C.;Colrain, Ian M.
通讯作者：
Colrain, Ian M.
影响因子：
4.3
作者：
Berryhill, Sarah;Morton, Christopher J.;Parthasarathy, Sairam
通讯作者：
Parthasarathy, Sairam