Sex steroidal hormones and respiratory control.
Sex steroidal hormones and respiratory control.
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DOI：
10.1016/j.resp.2008.06.006
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发表时间：
2008-12-10
影响因子：
2.3
通讯作者：
Wenninger, Julie M.
中科院分区：
文献类型：
--
作者：
Behan, Mary;Wenninger, Julie M.
公众越来越认识到性激素会对多种生理过程产生影响。然而，尽管经过近一个世纪的研究，我们仍然不清楚性激素对呼吸调节的影响。积累的大量数据表明，雌激素、孕激素和睾酮可以影响动物和人类的呼吸功能。阻塞性睡眠呼吸暂停 (OSA) 和婴儿猝死综合症 (SIDS) 等几种呼吸疾病的患病率存在明显的性别差异，这凸显了性激素在呼吸控制中的重要性。本综述重点关注以下问题：性激素多久会影响呼吸？哪个最有效？性激素在哪里发挥作用？涉及哪些机制？是否存在与年龄相关的变化？更清楚地了解性激素如何影响呼吸控制可以针对呼吸控制系统疾病进行针对性别和年龄的治疗干预。
There is a growing public awareness that sex hormones can have an impact on a variety of physiological processes. Yet, despite almost a century of research, we still do not have a clear picture as to the effects of sex hormones on the regulation of breathing. Considerable data has accumulated showing that estrogen, progesterone and testosterone can influence respiratory function in animals and humans. Several disorders of breathing such as obstructive sleep apnea (OSA) and sudden infant death syndrome (SIDS) show clear sex differences in their prevalence, lending weight to the importance of sex hormones in respiratory control. This review focuses on questions such as: How early do sex hormones influence breathing? Which is the most effective? Where do sex hormones exert their effects? What mechanisms are involved? Are there age-associated changes? A clearer understanding of how sex hormones influence the control of breathing could enable sex- and age-specific therapeutic interventions for diseases of the respiratory control system.
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