Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?
Altered Brain Fraction Amplitude of Low Frequency Fluctuation at Resting State in Patients With Early Left and Right Bell's Palsy: Do They Have Differences?
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DOI：
10.3389/fnins.2018.00797
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发表时间：
2018
影响因子：
4.3
通讯作者：
Ma G
中科院分区：
文献类型：
--
作者：
Han X;Li H;Wang X;Zhu Y;Song T;Du L;Sun S;Guo R;Liu J;Shi S;Fu C;Gao W;Zhang L;Ma G
目的：贝尔麻痹是指急性特发性单侧面神经麻痹。它是一种常见的障碍的主要运动途径的面部肌肉。本研究旨在探讨早期左右贝尔麻痹患者脑低频波动分数幅值（fALFF）的异常情况。材料和方法：67例患者（左33例，右34例）和37例年龄和性别匹配的健康对照进行静息状态功能磁共振成像（R-fMRI）检查。测量所有受试者的fALFF值，并在左瘫组、右瘫组和对照组之间进行比较。然后，分析患者的多伦多面部评分系统（Toronto Facial Grading System， TFGS）评分与异常脑区fALFF值的相关性。结果：三组间fALFF值的组间差异主要出现在大脑皮层、皮层下和深部灰质区。与右侧贝尔麻痹组比较，左侧贝尔麻痹组左侧颞上回颞极（TPOsup）、右侧边缘上皮层、左右中扣带皮层（MCC）、左侧额上回（SFG）和左侧中央前回（PreCG）的fALFF值均显著降低，右侧SFG和PreCG的fALFF值均升高。此外，改变的fALFF值与左侧上TPO、双侧MCC和右侧preg的TFGS评分呈正相关，与左侧贝尔麻痹组右侧SFG的TFGS评分呈负相关。改变的fALFF值与双侧MCC和右侧preg的TFGS评分呈正相关，与右侧贝尔麻痹组左侧上TPO和SFG的TFGS评分负相关。结论：左、右早期贝尔氏麻痹患者的调节机制存在差异。疾病的严重程度与这些功能改变有关。
Purpose: Bell’s palsy refers to acute idiopathic unilateral facial nerve palsy. It is a common disorder of the main motor pathway to the facial muscles. This study aimed to investigate the abnormal fraction amplitude of low frequency fluctuation (fALFF) of the brain in patients with early left and right Bell’s palsy. Materials and Methods: Sixty-seven patients (left 33, right 34) and 37 age- and sex-matched healthy controls underwent resting-state functional magnetic resonance imaging (R-fMRI) examination. The fALFF values were measured from all subjects and were compared among the left palsy, right palsy, and control groups. Then, correlations between the Toronto Facial Grading System (TFGS) scores of the patients and the fALFF values of abnormal brain regions were analyzed. Results: Significant group differences in fALFF values among the three groups were observed mainly in the cerebral cortical, subcortical, and deep gray matter regions. Compared with the right Bell’s palsy group, the left Bell’s palsy group showed significantly decreased fALFF values in the left temporal pole of the superior temporal gyrus (TPOsup), right supramarginal, left and right middle cingulate cortex (MCC), left superior frontal gyrus (SFG), and left precentral gyrus (PreCG), and increased fALFF values were observed in the right SFG and PreCG. Furthermore, altered fALFF values correlated positively with the TFGS scores in the left superior TPO, bilateral MCC, and right PreCG, and correlated negatively with the TFGS scores in the right SFG of the left Bell’s palsy group. Altered fALFF values correlated positively with the TFGS scores in the bilateral MCC and right PreCG and correlated negatively with the TFGS scores in the left superior TPO and SFG of the right Bell’s palsy group. Conclusion: Regulatory mechanisms seem to differ between patients with left and right early Bell’s palsy. The severity of the disease is associated with these functional alterations.
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影响因子：
3.3
作者：
Jiji, Sudevan;Smitha, Karavallil Achuthan;Jayasree, Ramapurath S.
通讯作者：
Jayasree, Ramapurath S.
影响因子：
5.7
作者：
Grefkes C;Nowak DA;Wang LE;Dafotakis M;Eickhoff SB;Fink GR
通讯作者：
Fink GR
DOI：
10.1016/b978-0-444-53485-9.00004-0
发表时间：
2016-01-01
期刊：
NEUROIMAGING, PT I
影响因子：
--
作者：
Buchbinder, Bradley R.
通讯作者：
Buchbinder, Bradley R.
影响因子：
2.6
作者：
Burmeister, Hartmut Peter;Baltzer, Pascal Andreas Thomas;Guntinas-Lichius, Orlando
通讯作者：
Guntinas-Lichius, Orlando
影响因子：
1.7
作者：
He X;Zhu Y;Li C;Park K;Mohamed AZ;Wu H;Xu C;Zhang W;Wang L;Yang J;Qiu B
通讯作者：
Qiu B