Long-term survival after surgical resection of metachronous lung, brain and thyroid gland metastases from rectal cancer: A case report.
Long-term survival after surgical resection of metachronous lung, brain and thyroid gland metastases from rectal cancer: A case report.
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DOI：
10.1016/j.ijscr.2021.01.054
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发表时间：
2021-03
影响因子：
0.6
通讯作者：
Sata N
中科院分区：
文献类型：
--
作者：
Rifu K;Koinuma K;Nishino H;Horie H;Lefor AK;Sata N
直肠癌脑和甲状腺转移不常见，预后较差。直肠癌的肺、脑和甲状腺转移异时切除。该病例在初次直肠手术后存活了 19 年。转移瘤被完全切除的患者可能会获得更长的生存期。直肠癌脑和甲状腺转移并不常见，预后较差。我们报告了一名直肠癌患者出现异时性肺、脑和甲状腺转移。每个转移病灶均被治愈性切除，从而延长了生存期。某60岁男性，行直肠癌切除术，病理诊断为管状腺癌，pT2，pN1a，M0，pⅢa期。直肠切除十年后，在左肺发现了一个孤立的肿瘤。胸腔镜下切除肿瘤，病理诊断为转移瘤。肺切除术三年后，发现了孤立性脑肿瘤。手术切除肿瘤，病理为转移瘤。脑切除两年后，检测到甲状腺肿块。进行了部分甲状腺切除术，免疫组织化学染色病理证实甲状腺病变是先前直肠癌的转移。甲状腺切除术后四年（初次直肠切除术后 19 年），他死于多发性肺和骨转移。结直肠转移至大脑和甲状腺的情况并不常见，通常与其他远处转移一起发现。据报道，总体生存率极低。在该患者中，肺、脑和甲状腺转移是孤立性和异时性的，并且每个病灶均被治愈性切除。手术治疗可能有助于延长生存期。每个患者的治疗策略应个体化，并取决于转移发生的时间。完全切除异时转移的选定患者可能会延长生存期。
Brain and thyroid metastasis of rectal cancer are uncommon, and prognosis are poor. Lung, brain and thyroid metastasis of rectal cancer was resected metachronous. This case survived 19 years after the initial rectal surgery. Patients whose metastases were resected completely may get a prolonged survival. Brain and thyroid metastasis from rectal cancer are uncommon, and the prognosis is poor. We report a patient with rectal cancer who developed metachronous lung, brain and thyroid metastases. Each metastatic lesion was curatively resected resulting in prolonged survival. A 60-year-old male underwent rectal cancer resection, and the pathological diagnosis was tubular adenocarcinoma, pT2,pN1a,M0, pStageⅢa. Ten years after rectal resection, a solitary tumor in the left lung was detected. The tumor was resected thoracoscopically and the pathological diagnosis was metastatic tumor. Three years after the pulmonary resection, a solitary brain tumor was detected. The tumor was removed surgically, and the pathology was metastatic tumor. Two years after brain resection, a thyroid mass was detected. A partial thyroidectomy was performed and the pathology with immunohistochemical staining confirmed the thyroid lesion as a metastasis from the previous rectal cancer. Four years after thyroid resection (19 years after the initial rectal resection), he died from multiple lung and bone metastases. Colorectal metastases to the brain and thyroid gland are uncommon and are usually found with other distant metastases. Overall survival has been reported to be extremely poor. In this patient, lung, brain, and thyroid metastases were solitary and metachronous, and each lesion was curatively resected. Surgical treatment might contribute to prolonged survival. The treatment strategy of each patient should be individualized and depends on the timing of metastasis development. Selected patients with complete resection of metachronous metastases may have prolonged survival.
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影响因子：
8.4
作者：
Lievre, Astrid;Leboulleux, Sophie;Malka, Dauid
通讯作者：
Malka, Dauid
影响因子：
15.3
作者：
Agha, Riaz A.;Borrelli, Mimi R.;Kasi, Veeru
通讯作者：
Kasi, Veeru
影响因子：
6.2
作者：
Kruser, Tim J.;Chao, Samuel T.;Suh, John H.
通讯作者：
Suh, John H.
影响因子：
3.9
作者：
Kalkanis, Steven N.;Kondziolka, Douglas;Gaspar, Laurie E.;Burri, Stuart H.;Asher, Anthony L.;Cobbs, Charles S.;Ammirati, Mario;Robinson, Paula D.;Andrews, David W.;Loeffler, Jay S.;McDermott, Michael;Mehta, Minesh P.;Mikkelsen, Tom;Olson, Jeffrey J.;Paleologos, Nina A.;Patchell, Roy A.;Ryken, Timothy C.;Linskey, Mark E.
通讯作者：
Linskey, Mark E.
DOI：
10.1038/nrclinonc.2014.25
发表时间：
2014-04
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
通讯作者：
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