Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.
Curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting IL-1beta and IL-6 production in mice.
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DOI：
10.1371/journal.pone.0067078
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hu J
中科院分区：
文献类型：
--
作者：
Sun J;Zhao Y;Hu J
姜黄素是一种选择性磷酸化酶激酶抑制剂，是姜黄中天然存在的植物化学物质。姜黄素已被证实具有抗炎特性，除了能够降低角质形成细胞中促炎细胞因子的表达。白细胞介素-23（IL-23）/IL-17 A细胞因子轴在银屑病的发病机制中起着关键作用。在这里，我们报告了局部使用姜黄素凝胶制剂强烈抑制咪喹莫特（IMQ）诱导的银屑病样炎症，其发展是基于IL-23/IL-17 A轴。姜黄素治疗后，IMQ诱导的BALB/c小鼠耳的表皮增生和炎症显着抑制。实时荧光定量PCR结果显示姜黄素可显著降低耳皮肤中IL-17 A、IL-17 F、IL-22、IL-1β、IL-6和TNF-α等细胞因子的mRNA水平，其作用与氯倍他索相似。此外，我们还发现姜黄素可促进表皮γδ T细胞的增殖，但抑制真皮γδ T细胞的增殖。我们推断姜黄素能够通过抑制IL-1β/IL-6然后间接下调IL-17 A/IL-22的产生来影响IL-23/IL-17 A轴。总之，姜黄素可以缓解小鼠模型中IMQ诱导的银屑病样炎症，与氯倍他索的作用相似。因此，我们有充分的理由期待姜黄素未来将用于银屑病的治疗。
Curcumin, a selective phosphorylase kinase inhibitor, is a naturally occurring phytochemical present in turmeric. Curcumin has been confirmed to have anti-inflammatory properties in addition to the ability to decrease the expression of pro-inflammatory cytokines in keratinocytes. The interleukin-23 (IL-23)/IL-17A cytokine axis plays a critical role in the pathogenesis of psoriasis. Here, we report that topical use of a curcumin gel formulation strongly inhibited imiquimod (IMQ)-induced psoriasis-like inflammation, the development of which was based on the IL-23/IL-17A axis. IMQ-induced epidermal hyperplasia and inflammation in BALB/c mouse ear was significantly inhibited following curcumin treatment. Real-time PCR showed that mRNA levels of IL-17A, IL-17F, IL-22, IL-1β, IL-6 and TNF-α cytokines were decreased significantly by curcumin in ear skin, an effect similar to that of clobetasol. In addition, we found that curcumin may enhance the proliferation of epidermis γδ T cells but inhibit dermal γδ T cell proliferation. We inferred that curcumin was capable of impacting the IL-23/IL-17A axis by inhibiting IL-1β/IL-6 and then indirectly down-regulating IL-17A/IL-22 production. In conclusion, curcumin can relieve the IMQ-induced psoriasis-like inflammation in a mouse model, similar to the effects of clobetasol. Therefore, we have every reason to expect that curcumin will be used in the treatment of psoriasis in the future.
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