Physics of Cellular Movements

Physics of Cellular Movements
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细胞运动物理学

DOI:
10.1146/annurev-conmatphys-070909-104105
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发表时间:
2010
影响因子:
22.6
通讯作者:
D. Heinrich
D. Heinrich
中科院分区:
物理与天体物理1区
文献类型:
--
作者:
E. Sackmann;F. Keber;D. Heinrich

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细胞的存活依赖于永久的主动运动,包括(a)软细胞包膜的弯曲激发,(B)细胞中心和外周之间物质和细胞器的双向运输,以及(c)细胞内大分子支架的持续重构,其介导与细胞粘附运动和吞噬作用相关的整体细胞变化。解决的主要问题如下:如何描述和测量这种极其复杂的软结构的熙熙攘攘的运动?主要驱动力是什么?进一步的主题包括:(a)主动动态控制的全球形状变化的相互作用耦合的紫菀样软支架的微管和网络的肌动蛋白丝与细胞包膜(肌动蛋白皮层)和(B)的产生推进力的肌动蛋白凝胶化波内传播的肌动蛋白皮层。
The survival of cells depends on perpetual active motions, including (a) bending excitations of the soft cell envelopes, (b) the bidirectional transport of materials and organelles between the cell center and the periphery, and (c) the ongoing restructuring of the intracellular macromolecular scaffolds mediating global cell changes associated with cell adhesion locomotion and phagocytosis. Central questions addressed are the following: How can this bustling motion of extremely complex soft structures be characterized and measured? What are the major driving forces? Further topics include (a) the active dynamic control of global shape changes by the interactive coupling of the aster-like soft scaffold of microtubules and the network of actin filaments associated with the cell envelope (the actin cortex) and (b) the generation of propulsion forces by solitary actin gelation waves propagating within the actin cortex.
DOI: 10.1073/pnas.85.16.5946
发表时间: 1988-08-01
影响因子: 11.1
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