Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice.

Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice.
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C3H/HeJ 小鼠被蜱虫叮咬后,局部抗生素未能预防播散性伯氏疏螺旋体感染。

DOI:
10.1093/infdis/jir382
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发表时间:
2012
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Pavia,CharlesS
Pavia,CharlesS
中科院分区:
--
文献类型:
--
作者:
Wormser,GaryP;Daniels,ThomasJ;Bittker,Susan;Cooper,Denise;Wang,Guiqing;Pavia,CharlesS

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A prior study in mice has shown that the timely application of topical antibiotics to the skin at the tick bite site could eradicateBorrelia burgdorferiinfection. That study, however, did not evaluate antibiotic preparations that are considered suitable for use in humans. In this murine study, topical application of 2% erythromycin and 3% tetracycline preparations that are acceptable for use in humans was found to be ineffective in eliminatingB. burgdorferifrom the tick bite site or in preventing dissemination to other tissues. Reasons for the discrepant findings are discussed.
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