Alcohol intake and the risk of age-related cataracts: a meta-analysis of prospective cohort studies.
Alcohol intake and the risk of age-related cataracts: a meta-analysis of prospective cohort studies.
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酒精摄入量和年龄相关性白内障的风险：前瞻性队列研究的荟萃分析
DOI：
10.1371/journal.pone.0107820
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Wang W;Zhang X
流行病学研究评估了饮酒与年龄相关性白内障（arc）风险之间的关系，结果不一致。本荟萃分析是为了填补这一空白。通过计算机检索和查阅这些获得的文献的参考文献列表来确定符合条件的研究。使用随机效应模型计算相对风险（RR）和相应的95%置信区间（CI）的汇总估计。这项荟萃分析最终纳入了7项前瞻性队列研究，共涉及119,706名参与者。综合结果显示，大量饮酒并没有显著增加ARC的总体风险。重度饮酒者与非饮酒者相比，白内障手术的相对危险度分别为1.25 (95% CI: 1.00, 1.56)，皮质性白内障的相对危险度为1.06 (95% CI: 0.63, 1.81)，核性白内障的相对危险度为1.26 (95% CI: 0.93, 1.73)，后囊下白内障（PSCs）的相对危险度为0.91 （95% CI: 0.32, 2.61）。没有观察到适度饮酒与白内障之间的显著关联。中度饮酒者与不饮酒者的总相对危险度分别为：白内障手术0.90 (95% CI: 0.64, 1.26)，皮质性白内障0.97 (95% CI: 0.75, 1.25)，核性白内障0.91 (95% CI: 0.76, 1.08), psc 0.97 （95% CI: 0.49, 1.91）。这项荟萃分析表明，酒精摄入并没有显著增加ARC的总体风险。由于研究数量有限，我们的研究结果必须通过精心设计的队列研究或干预研究在未来的研究中得到证实。
Epidemiologic studies assessing the relationship between alcohol consumption and the risk of age-related cataracts (ARCs) led to inconsistent results. This meta-analysis was performed to fill this gap. Eligible studies were identified via computer searches and reviewing the reference lists of these obtained articles. Pooled estimates of the relative risks (RR) and the corresponding 95% confidence Intervals (CI) were calculated using random effects models. Seven prospective cohort studies involving a total of 119,706 participants were ultimately included in this meta-analysis. Pooled results showed that there is no substantial overall increased risk of ARC due to heavy alcohol consumption. The estimated RRs comparing heavy drinkers versus non-drinkers were 1.25 (95% CI: 1.00, 1.56) for cataract sugery, 1.06 (95% CI: 0.63, 1.81) for cortical cataracts, 1.26 (95% CI: 0.93, 1.73) for nuclear cataracts, and 0.91 (95% CI: 0.32, 2.61) for posterior subcapsular cataracts (PSCs), respectively. No significant associations between moderate alcohol consumption and cataracts were observed. The pooled RRs comparing moderate drinkers versus non-drinkers were 0.90 (95% CI: 0.64, 1.26) for cataract surgery, 0.97 (95% CI: 0.75, 1.25) for cortical cataracts, 0.91 (95% CI: 0.76, 1.08) for nuclear cataracts, and 0.97 (95% CI: 0.49, 1.91) for PSCs, respectively. This meta-analysis suggests that there is no substantial overall increased risk of ARC due to alcohol intake. Because of the limited number of studies, the findings from our study must be confirmed in future research via well-designed cohort or intervention studies.
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