Macrophages in neovascular age-related macular degeneration: friends or foes?

Macrophages in neovascular age-related macular degeneration: friends or foes?
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DOI:
10.1038/eye.2008.206
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发表时间:
2009-04
期刊:
Eye (London, England)
影响因子:
--
通讯作者:
Mullins RF
Mullins RF
中科院分区:
其他
文献类型:
--
作者:
Skeie JM;Mullins RF

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The events that lead to choroidal neovascularization in eyes with age-related macular degeneration are poorly understood. One possibility that has been explored in a number of studies is that macrophages can promote neovascular changes. In this manuscript we summarize the evidence for inflammation in general and macrophages in particular in pathologic neovascularization, and discuss how the diverse functions of these cells may promote or inhibit macular disease. We also discuss some of the conflicting findings regarding the role of macrophages in experimental choroidal neovascularization in mouse models, and suggest areas for future research.
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