A simple and low-cost approach for irreversible bonding of polymethylmethacrylate and polydimethylsiloxane at room temperature for high-pressure hybrid microfluidics.
A simple and low-cost approach for irreversible bonding of polymethylmethacrylate and polydimethylsiloxane at room temperature for high-pressure hybrid microfluidics.
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一种用于高压混合微流控中聚甲基丙烯酸甲酯和聚二甲基硅氧烷在室温下不可逆键合的简单且低成本的方法。
DOI：
10.1038/s41598-021-83011-8
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发表时间：
2021-03-01
影响因子：
4.6
通讯作者：
Sen A
中科院分区：
文献类型：
--
作者：
Hassanpour-Tamrin S;Sanati-Nezhad A;Sen A
微流控设备由于其提供的优势，如相对低成本，快速和精确的处理，以及支持高度自动化分析的能力，已逐步用于生物医学研究。聚二甲基硅氧烷（PDMS）和聚甲基丙烯酸甲酯（PMMA）由于其理想的特性而被广泛用于微流体中的生物相容性材料。人们认识到，在单个微流体装置中组合这两种特定材料将使得能够开发需求日益增加的一系列新应用，包括那些需要高流速和高压的应用。尽管已经报道了用于粘合这两种材料的复杂且耗时的努力，但PDMS和PMMA的稳健粘合尚未实现，并且仍然是一个挑战。在这项研究中，一种新的，简单的，有效的，低成本的方法已被开发出来，在室温下，在不到5分钟的时间内，使用生物相容性胶带和氧等离子体处理介导PMMA和PDMS层之间的强键。PDMS-PMMA键是水解稳定的，并且可以耐受高的流体流入而没有任何泄漏。这项研究解决了现有方法结合这些材料的局限性，并将使高度寻求高压和高通量生物医学应用的发展。
Microfluidic devices have been used progressively in biomedical research due to the advantages they offer, such as relatively low-cost, rapid and precise processing, and an ability to support highly automated analyses. Polydimethylsiloxane (PDMS) and polymethylmethacrylate (PMMA) are both biocompatible materials widely used in microfluidics due to their desirable characteristics. It is recognized that combining these two particular materials in a single microfluidic device would enable the development of an increasingly in-demand array of new applications, including those requiring high flow rates and elevated pressures. Whereas complicated and time-consuming efforts have been reported for bonding these two materials, the robust adhesion of PDMS and PMMA has not yet been accomplished, and remains a challenge. In this study, a new, simple, efficient, and low-cost method has been developed to mediate a strong bond between PMMA and PDMS layers at room temperature in less than 5 min using biocompatible adhesive tape and oxygen plasma treatment. The PDMS–PMMA bond was hydrolytically stable, and could tolerate a high influx of fluid without any leakage. This study addresses the limitations of existing approaches to bond these materials, and will enable the development of highly sought high-pressure and high-throughput biomedical applications.
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影响因子：
3.1
作者：
Chang, Yongjia;You, Hui
通讯作者：
You, Hui
影响因子：
4.6
作者：
Matellan C;Del Río Hernández AE
通讯作者：
Del Río Hernández AE
DOI：
10.1016/s0143-7496(01)00018-5
发表时间：
2001-10-01
影响因子：
3.4
作者：
de Buyl, F
通讯作者：
de Buyl, F
DOI：
10.1016/b978-0-12-381422-7.10033-1
发表时间：
2011-01-01
期刊：
PRINCIPLES OF REGENERATIVE MEDICINE, 2ND EDITION
影响因子：
--
作者：
Hacker, M. C.;Mikos, A. G.
通讯作者：
Mikos, A. G.
影响因子：
6.1
作者：
Kim, Jungkyu;Surapaneni, Rajesh;Gale, Bruce K.
通讯作者：
Gale, Bruce K.