Protein quality control at the plasma membrane.
Protein quality control at the plasma membrane.
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DOI：
10.1016/j.ceb.2011.04.012
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发表时间：
2011-08
影响因子：
7.5
通讯作者：
Lukacs, Gergely L.
中科院分区：
文献类型：
--
作者：
Okiyoneda, Tsukasa;Apaja, Pirjo M.;Lukacs, Gergely L.
细胞蛋白质稳态（或蛋白质稳态）依赖于构象受损多肽在其生命周期内所有亚细胞位置的及时折叠和处置。这一过程对局限于细胞表面的膜蛋白尤其重要，在细胞内平衡和细胞间通讯中起着关键的调节作用。越来越多的证据表明，从内质网（ER）输出的膜蛋白沿着分泌和内吞途径以及质膜（PM）受到外周质量控制（QC）。最近发现的PM QC识别组件和负责泛素化和构象受损PM蛋白溶酶体降解的效应机制揭示了与ER QC机制的惊人相似性和差异性。还概述了外周蛋白QC活性在构象疾病的表型调节中的可能含义。
Cellular proteostasis (or protein homeostasis) depends on the timely folding and disposal of conformationally damaged polypeptides during their life span at all subcellular locations. This process is particularly important for membrane proteins confined to the cell surface with critical regulatory role in cellular homoeostasis and intercellular communication. Accumulating evidences indicate that membrane proteins exported from the endoplasmic reticulum (ER) are subjected to peripheral quality control (QC) along the late secretory and endocytic pathways, as well as at the plasma membrane (PM). Recently identified components of the PM QC recognition and effector mechanisms responsible for ubiquitination and lysosomal degradation of conformationally damaged PM proteins uncovered striking similarities to and differences from that of the ER QC machinery. Possible implications of the peripheral protein QC activity in phenotypic modulation of conformational diseases are also outlined.
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DOI：
10.1083/jcb.200808124
发表时间：
2009-03-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Glozman R;Okiyoneda T;Mulvihill CM;Rini JM;Barriere H;Lukacs GL
通讯作者：
Lukacs GL
DOI：
10.1073/pnas.161282998
发表时间：
2001-07-31
影响因子：
11.1
作者：
Gong, XH;Chang, A
通讯作者：
Chang, A
影响因子：
3.6
作者：
Hayashi, Hisamitsu;Sugiyama, Yuichi
通讯作者：
Sugiyama, Yuichi
影响因子：
13.3
作者：
Gurusamy, Narasimman;Lekli, Istyan;Das, Dipak K.
通讯作者：
Das, Dipak K.
影响因子：
2.9
作者：
Li, Jian-Guo;Chen, Chongauang;Liu-Chen, Lee-Yuan
通讯作者：
Liu-Chen, Lee-Yuan