Effect of single oral dose of sodium benzoate on ureagenesis in healthy men and two patients with late onset citrullinaemia
Effect of single oral dose of sodium benzoate on ureagenesis in healthy men and two patients with late onset citrullinaemia
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单次口服苯甲酸钠对健康男性和两名晚发瓜氨酸血症患者尿素生成的影响
DOI：
--
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发表时间：
2004
影响因子：
2.9
通讯作者：
T. Ishizaki
中科院分区：
文献类型：
--
作者：
K. Kubota;T. Ishizaki
尽管苯甲酸钠治疗对先天性尿素循环错误的患者是有益的，但有研究表明，苯甲酰辅酶a的积累会抑制尿素生成。在这项研究中，我们检查了6名参加先前研究的健康受试者和2名瓜氨酸血症患者在单次口服苯甲酸钠后的几个方面的尿毒症。4、80、160 mg·kg - 1苯甲酸钠处理后，6名健康受试者的尿素氮形态（UNA）无明显变化。UNA和尿尿氮（UHN）随剂量的增加而增加。在2例受益于部分功能尿素循环的晚发性瓜氨酸血症患者中，施用80 mg/kg苯甲酸钠后未观察到对UNA的明显抑制作用。6例正常人和2例瓜氨酸血症患者服用苯甲酸酯后，尿素前体（氨、谷氨酸、谷氨酰胺和α-氨基氮）均未升高。
SummaryAlthough sodium benzoate therapy is beneficial in patients with inborn error of urea cycle, it has been suggested that an accumulation of benzoyl-CoA would inhibit ureagenesis. In this study, we examined several aspects of ureagenesis after the single oral dosing of sodium benzoate in six healthy subjects who participated in the study previously reported and in two patients with citrullinaemia.Urea nitrogen appearance (UNA) did not change after the doses of 40, 80 and 160 mg·kg−1 of sodium benzoate in the 6 healthy subjects. Sum of UNA and urinary hippurate nitrogen (UHN) increased with increasing the dose. In the 2 patients with late-onset citrullinaemia who benefit from a partially functional urea cycle, no apparent inhibitory effects on the UNA were observed after the administration of 80 mg/kg of sodium benzoate.The precursors of urea (ammonia, glutamate, glutamine and α-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.
苯甲酸盐引起慢性肾功能衰竭患者甘氨酸和尿素代谢的变化。
DOI：
--
发表时间：
1982
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Mitch,WE;Brusilow,S
通讯作者：
Brusilow,S
苯甲酸钠对大鼠氨毒性的影响。
DOI：
10.1016/0006-291x(86)90290-1
发表时间：
1986
影响因子：
3.1
作者：
Maswoswe,SM;Cyr,DM;Griffith,AD;Tremblay,GC
通讯作者：
Tremblay,GC