Cellular and mitochondrial effects of alcohol consumption.
Cellular and mitochondrial effects of alcohol consumption.
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DOI：
10.3390/ijerph7124281
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发表时间：
2010-12
影响因子：
--
通讯作者：
Saavedra-Molina A
中科院分区：
文献类型：
--
作者：
Manzo-Avalos S;Saavedra-Molina A
酒精依赖与广泛的医疗，心理，行为和社会问题有关。急性酒精滥用会导致几个器官的损害和功能障碍，影响蛋白质、碳水化合物和脂肪代谢。线粒体参与乙醛转化为乙酸盐和生成增加量的NADH。胎儿发育期间产前暴露于乙醇会对后代产生广泛的不良影响，如神经系统异常和出生前和出生后生长迟缓。由于酒精饮料含有不同的化合物，如多酚和白藜芦醇，因此已经描述了抗氧化作用。这篇综述分析了酒精消费对几个人体器官的影响的不同主题，并证明了线粒体作为可用于预防酒精滥用者治疗的化合物的潜在靶点的直接参与。
Alcohol dependence is correlated with a wide spectrum of medical, psychological, behavioral, and social problems. Acute alcohol abuse causes damage to and functional impairment of several organs affecting protein, carbohydrate, and fat metabolism. Mitochondria participate with the conversion of acetaldehyde into acetate and the generation of increased amounts of NADH. Prenatal exposure to ethanol during fetal development induces a wide spectrum of adverse effects in offspring, such as neurologic abnormalities and pre- and post-natal growth retardation. Antioxidant effects have been described due to that alcoholic beverages contain different compounds, such as polyphenols as well as resveratrol. This review analyzes diverse topics on the alcohol consumption effects in several human organs and demonstrates the direct participation of mitochondria as potential target of compounds that can be used to prevent therapies for alcohol abusers.
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DOI：
10.1152/ajpgi.00044.2006
发表时间：
2006-11-01
影响因子：
4.5
作者：
Bailey, Shannon M.;Robinson, Gloria;Darley-Usmar, Victor
通讯作者：
Darley-Usmar, Victor
影响因子：
3.6
作者：
Cheng, TH;Liu, JC;Chen, JJ
通讯作者：
Chen, JJ
影响因子：
5
作者：
Churchill, Eric N.;Disatnik, Marie-Helene;Mochly-Rosen, Daria
通讯作者：
Mochly-Rosen, Daria
影响因子：
120.7
作者：
BLUM, K;NOBLE, EP;COHN, JB
通讯作者：
COHN, JB
影响因子：
64.8
作者：
Baur, Joseph A.;Pearson, Kevin J.;Sinclair, David A.
通讯作者：
Sinclair, David A.