Morphological Study of the Effect of Aerobic Exercise on Organs and Arteries in Spontaneously Hypertensive Rats.
Morphological Study of the Effect of Aerobic Exercise on Organs and Arteries in Spontaneously Hypertensive Rats.
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DOI：
10.3390/healthcare9081066
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发表时间：
2021-08-19
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Xiong Y;Luan Y;Zhang B;Zhang S;Wang X
高血压病常伴有器官和动脉损害，严重威胁人类健康。有氧运动能有效防治高血压。然而，运动疗法治疗高血压的机制尚不清楚。本研究从病理形态学角度探讨有氧运动如何有效逆转高血压对心、肾、动脉的损害。对自发性高血压大鼠进行为期15周的45 min和90 min的无负重游泳训练，观察运动对心脏、肾脏、髂动脉和肠系膜动脉分支形态结构的影响。结果发现，有氧运动45 min后，心肌纤维变细，心肌细胞横截面积减小，心肌细胞水肿消失。肾小球和肾小管的病理形态学改变也得到改善。同时，有氧运动还可逆转自发性高血压大鼠动脉及肠系膜动脉分支的形态结构。
Hypertension is usually accompanied by the impairment of organs and arteries, and seriously threatens human health. Aerobic exercise can effectively prevent and treat hypertension. However, the mechanism of exercise therapy in hypertension is still unclear. In this study, we explored how aerobic exercise effectively reversed the impairment of the heart, kidney, and arteries caused by hypertension through a pathomorphological perspective. Spontaneously hypertensive rats were subjected to fifteen weeks of 45 min and 90 min swimming training without weight, and we then tested the effect of exercise on the morphology and structure of the heart, kidney, iliac artery, and branch of the mesenteric artery. We found that the myocardial fibers became thinner, the cross-sectional area of myocardial cells decreased, and cardiomyocyte edema disappeared after 45 min of aerobic exercise. Additionally, the pathological microstructure of glomeruli and renal tubules were improved. At the same time, aerobic exercise could also reverse the morphology and structure of arteries and mesenteric artery branches in spontaneously hypertensive rats.
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DOI：
10.1038/s41581-019-0244-2
发表时间：
2020-04
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Mills KT;Stefanescu A;He J
通讯作者：
He J
影响因子：
3.9
作者：
Chen, Yu;Zhang, Yanyan;Shi, Lijun
通讯作者：
Shi, Lijun
影响因子：
2.8
作者：
Duan, Yong-Chang;Shi, Lin;Zhang, Kun-Ru
通讯作者：
Zhang, Kun-Ru
影响因子：
4.6
作者：
Guo X;Chen H;Han L;Haulon S;Kassab GS
通讯作者：
Kassab GS
影响因子：
8.3
作者：
Melo, RM;Martinho, E;Michelini, LC
通讯作者：
Michelini, LC