Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity.
Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity.
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DOI：
10.1016/j.cell.2022.03.018
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发表时间：
2022-04-28
期刊：
影响因子：
64.5
通讯作者：
Pepper M
中科院分区：
文献类型：
--
作者：
Rodda LB;Morawski PA;Pruner KB;Fahning ML;Howard CA;Franko N;Logue J;Eggenberger J;Stokes C;Golez I;Hale M;Gale M Jr;Chu HY;Campbell DJ;Pepper M
免疫记忆是由淋巴细胞在启动过程中感知的线索定制的。严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行创造了一种情况，即通过额外的抗原暴露可以追踪新生记忆。SARS-CoV-2感染和疫苗接种都能诱导多方面的功能性免疫记忆，但两者结合起来，可以提高对疾病的保护，称为混合免疫。因此，我们研究了疫苗诱导的记忆是如何通过先前的感染形成的。我们发现，接种疫苗后，先前感染的个体比先前未感染的个体产生更多的SARS-CoV-2 RBD特异性记忆B细胞和变体中和抗体，以及表达IFN-γ和IL-10的记忆SARS-CoV-2刺突特异性CD 4 + T细胞的独特群体。虽然额外的疫苗接种可以增加体液记忆在以前的天真的个人，它并没有概括不同的CD 4 + T细胞细胞因子的档案中观察到以前感染的科目。因此，SARS-CoV-2特异性记忆淋巴细胞的印记特征定义了杂交免疫。先前感染过SARS-CoV-2的接种个体对SARS-CoV-2的强免疫力可以通过RBD特异性记忆B细胞、变体中和抗体和特异性CD 4 + T细胞群的组合来解释。
Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen exposures. Both SARS-CoV-2 infection and vaccination induce multifaceted, functional immune memory, but together, they engender improved protection from disease, termed hybrid immunity. We therefore investigated how vaccine-induced memory is shaped by previous infection. We found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-γ and IL-10-expressing memory SARS-CoV-2 spike-specific CD4+ T cells than previously naive individuals. Although additional vaccination could increase humoral memory in previously naive individuals, it did not recapitulate the distinct CD4+ T cell cytokine profile observed in previously infected subjects. Thus, imprinted features of SARS-CoV-2-specific memory lymphocytes define hybrid immunity. The strong immunity against SARS-CoV-2 in vaccinated individuals that have previously been infected can be explained by a combination of RBD-specific memory B cells, variant-neutralizing antibodies, and a specific population of CD4+ T cells.
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mRNA疫苗会诱导SARS-COV-2和关注的变体诱导耐用的免疫记忆。
DOI：
10.1126/science.abm0829
发表时间：
2021-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1126/science.abm3425
发表时间：
2022-01-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
64.8
作者：
Cho A;Muecksch F;Schaefer-Babajew D;Wang Z;Finkin S;Gaebler C;Ramos V;Cipolla M;Mendoza P;Agudelo M;Bednarski E;DaSilva J;Shimeliovich I;Dizon J;Daga M;Millard KG;Turroja M;Schmidt F;Zhang F;Tanfous TB;Jankovic M;Oliveria TY;Gazumyan A;Caskey M;Bieniasz PD;Hatziioannou T;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
30.5
作者：
Galani, Ioanna-Evdokia;Rovina, Nikoletta;Andreakos, Evangelos
通讯作者：
Andreakos, Evangelos