Low-ω3 Fatty Acid and Soy Protein Attenuate Alcohol-Induced Fatty Liver and Injury by Regulating the Opposing Lipid Oxidation and Lipogenic Signaling Pathways.
Low-ω3 Fatty Acid and Soy Protein Attenuate Alcohol-Induced Fatty Liver and Injury by Regulating the Opposing Lipid Oxidation and Lipogenic Signaling Pathways.
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DOI：
10.1155/2016/1840513
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发表时间：
2016
影响因子：
--
通讯作者：
Lakshman MR
中科院分区：
文献类型：
--
作者：
Reyes-Gordillo K;Shah R;Varatharajalu R;Garige M;Leckey LC;Lakshman MR
慢性乙醇诱导的过氧化物酶体增殖物激活受体γ辅激活因子1-α（PGC 1 α）下调和过氧化物酶体增殖物激活受体γ辅激活因子1-β（PGC 1 β）上调分别影响肝脏脂质氧化和脂肪生成，导致脂肪肝损伤。主要调节PGC 1 α的低ω3脂肪酸（Low-ω3FA）和似乎对PGC 1 β具有主要调节作用的大豆蛋白（SP）在喂食Lieber-deCarli对照或含高或低ω3FA鱼油和大豆蛋白的乙醇液体饲料的大鼠中评价了其对乙醇诱导的脂肪肝的保护作用。低ω3FA和SP通过降低血清和肝脏脂质以及伴随的脂肪肝减少来对抗慢性乙醇的作用。它们还通过5′腺苷单磷酸活化蛋白激酶（AMPK）的磷酸化阻止肝Sirtuin 1（SIRT 1）和PGC 1 α及其靶向脂肪酸氧化途径基因的下调，并减弱肝PGC 1 β和固醇调节元件结合蛋白1c（SREBP 1c）及其靶向脂肪生成途径基因的上调。因此，这两种新型调节剂可能通过调节两种相反的脂质氧化和脂肪生成途径来减弱乙醇诱导的脂肪肝和随后的肝损伤。
Chronic ethanol-induced downregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC1β) affect hepatic lipid oxidation and lipogenesis, respectively, leading to fatty liver injury. Low-ω3 fatty acid (Low-ω3FA) that primarily regulates PGC1α and soy protein (SP) that seems to have its major regulatory effect on PGC1β were evaluated for their protective effects against ethanol-induced hepatosteatosis in rats fed with Lieber-deCarli control or ethanol liquid diets with high or low ω3FA fish oil and soy protein. Low-ω3FA and SP opposed the actions of chronic ethanol by reducing serum and liver lipids with concomitant decreased fatty liver. They also prevented the downregulation of hepatic Sirtuin 1 (SIRT1) and PGC1α and their target fatty acid oxidation pathway genes and attenuated the upregulation of hepatic PGC1β and sterol regulatory element-binding protein 1c (SREBP1c) and their target lipogenic pathway genes via the phosphorylation of 5′ adenosine monophosphate-activated protein kinase (AMPK). Thus, these two novel modulators attenuate ethanol-induced hepatosteatosis and consequent liver injury potentially by regulating the two opposing lipid oxidation and lipogenic pathways.
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影响因子：
4.8
作者：
DAVIDSON, WS;GILLOTTE, KL;PHILLIPS, MC
通讯作者：
PHILLIPS, MC
DOI：
10.1124/jpet.102.047217
发表时间：
2003-09-01
影响因子：
3.5
作者：
Enomoto, N;Takei, Y;Sato, N
通讯作者：
Sato, N
影响因子：
10.5
作者：
Kim, JB;Spiegelman, BM
通讯作者：
Spiegelman, BM
影响因子：
13.5
作者：
Lu, Yongke;Zhuge, Jian;Cederbaum, Arthur I.
通讯作者：
Cederbaum, Arthur I.
影响因子：
9.8
作者：
Marmillot, P;Rao, MN;Lakshman, MR
通讯作者：
Lakshman, MR