Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
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通过结合来自8，130名2型糖尿病（T2 D）患者和38，987名欧洲血统对照的全基因组关联数据，并在另外34，412例病例和59，925名对照中随访先前未识别的荟萃分析信号，我们确定了12个新的T2 D关联信号，组合P < 5 × 10−8。这些包括KCNQ 1基因座上的第二个独立信号;据我们所知，X染色体相关性的第一份报告（靠近DUSP 9）;以及涉及单基因和多因素糖尿病形式的基因座之间重叠的另一个例子（在HNF 1A）。所鉴定的基因座影响β细胞功能和胰岛素作用，并且总体而言，T2 D关联信号显示参与细胞周期调控的基因富集的证据。我们还表明，高比例的T2 D易感基因座具有独立的关联信号，影响明显不相关的复杂性状。
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combinedP < 5 × 10−8. These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
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影响因子：
3.7
作者：
Gordon WR;Vardar-Ulu D;L'Heureux S;Ashworth T;Malecki MJ;Sanchez-Irizarry C;McArthur DG;Histen G;Mitchell JL;Aster JC;Blacklow SC
通讯作者：
Blacklow SC
影响因子：
5.8
作者：
Hegele, RA;Cao, HI;Zinman, B
通讯作者：
Zinman, B
新的遗传基因座涉及禁食葡萄糖稳态及其对2型糖尿病风险的影响。
影响因子：
30.8
作者：
通讯作者：
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影响因子：
3.5
作者：
Brants, JR;Ayoubi, TAY;Petit, MMR
通讯作者：
Petit, MMR
影响因子：
5.2
作者：
Cleynen, Isabelle;Brants, Jan R.;Petit, Marleen M. R.
通讯作者：
Petit, Marleen M. R.