The magnitude of nocebo effects in pain: a meta-analysis.
The magnitude of nocebo effects in pain: a meta-analysis.
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DOI：
10.1016/j.pain.2014.04.016
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发表时间：
2014-08
期刊：
影响因子：
7.4
通讯作者：
Vase L
中科院分区：
文献类型：
--
作者：
Petersen GL;Finnerup NB;Colloca L;Amanzio M;Price DD;Jensen TS;Vase L
反安慰剂效应的研究正在不断发展，一些文献综述已经出现，然而，到目前为止，没有量化这种影响。这项荟萃分析调查了反安慰剂对疼痛的影响。我们检索了PubMed、EMBASE、Scopus和Cochrane对照试验注册数据库中“反安慰剂”一词。只有那些调查反安慰剂效应的研究才符合条件，这些研究是指在进行惰性治疗的同时口头暗示症状恶化，并包括不进行治疗的控制条件。10项研究符合选择标准。效应量采用Cohen ' s d和Hedges ' s g进行计算。反安慰剂效应的总体大小为中等到较大(最低g = 0.62（0.24-1.01)，最高g = 1.03(0.63-1.43)）和高度可变（g = - 0.43-4.05）。在机制研究中，效应量的大小和范围与安慰剂效应相似（d = 0.81）。在由言语暗示和条件反射联合诱导反安慰剂效应的研究中，效应大小（最低g = 0.76（0.39-1.14）和最高g = 1.17(0.52-1.81)）大于仅由言语暗示诱导反安慰剂效应的研究（最低g = 0.64（- 0.25-1.53）和最高g = 0.87(0.40-1.34)）。这些发现与安慰剂文献中的发现相似。由于反安慰剂效应的大小是可变的，有时甚至很大，因此本荟萃分析表明在临床实践中尽量减少反安慰剂效应的重要性。
The investigation of nocebo effects is evolving and a few literature reviews have emerged, however, so far without quantifying such effects. This meta-analysis investigated nocebo effects in pain. We searched the databases PubMed, EMBASE, Scopus, and the Cochrane Controlled Trial Register with the term “nocebo”. Only studies that investigated nocebo effects as the effects that follow the administration of an inert treatment along with verbal suggestions of symptom worsening and that included a no-treatment control condition were eligible. Ten studies fulfilled the selection criteria. The effect sizes were calculated using Cohen’s d and Hedges’ g. The overall magnitude of the nocebo effect was moderate to large (lowest g = 0.62 (0.24-1.01) and highest g = 1.03 (0.63-1.43)) and highly variable (range of g = −0.43-4.05). The magnitudes and range of effect sizes was similar to those of placebo effects (d = 0.81) in mechanistic studies. In studies where nocebo effects were induced by a combination of verbal suggestions and conditioning, the effect size was larger (lowest g = 0.76 (0.39-1.14) and highest g = 1.17 (0.52-1.81)) than in studies where nocebo effects were induced by verbal suggestions alone (lowest g = 0.64 (−0.25-1.53) and highest g = 0.87 (0.40-1.34)). These findings are similar to those in the placebo literature. Since the magnitude of the nocebo effect is variable and sometimes large, this meta-analysis demonstrates the importance of minimizing nocebo effects in clinical practice.
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影响因子：
6.2
作者：
de la Cruz, Maxine;Hui, David;Parsons, Henrique A.;Bruera, Eduardo
通讯作者：
Bruera, Eduardo
影响因子：
2.5
作者：
Colloca, Luana;Benedetti, Fabrizio
通讯作者：
Benedetti, Fabrizio
DOI：
10.1111/j.1365-2982.2012.01950.x
发表时间：
2012-10-01
期刊：
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
影响因子：
--
作者：
Elsenbruch, S;Schmid, J;Benson, S
通讯作者：
Benson, S
影响因子：
3.3
作者：
Flaten, MA;Simonsen, T;Olsen, H
通讯作者：
Olsen, H
DOI：
10.1001/jama.1955.02960340022006
发表时间：
1955-01-01
影响因子：
120.7
作者：
BEECHER, HK
通讯作者：
BEECHER, HK