The Niche-Dependent Feedback Loop Generates a BMP Activity Gradient to Determine the Germline Stem Cell Fate
The Niche-Dependent Feedback Loop Generates a BMP Activity Gradient to Determine the Germline Stem Cell Fate
复制标题
生态位依赖性反馈环路生成 BMP 活性梯度来确定生殖干细胞的命运
DOI：
10.1016/j.cub.2012.01.056
复制
发表时间：
2012-03
期刊：
影响因子：
9.2
通讯作者：
Chen, Dahua
中科院分区：
文献类型：
--
作者：
Zhang, Guoqiang;Wang, Hailong;Tao, Yi;Chen, Dahua
Stem cells interact with surrounding stromal cells (or niche) via signaling pathways to precisely balance stem cell self-renewal and differentiation [1–4]. However, little is known about how niche signals are transduced dynamically and differentially to stem cells and their intermediate progeny and how the fate switch of stem cell to differentiating cell is initiated. TheDrosophilaovarian germline stem cells (GSCs) have provided a heuristic model for studying the stem cell and niche interaction. Previous studies demonstrated that the niche-dependent BMP signaling is essential for GSC self-renewal via silencingbamtranscription in GSCs [5–7]. We recently revealed that the Fused (Fu)/Smurf complex degrades the BMP type I receptor Tkv allowing forbamexpression in differentiating cystoblasts (CBs) [8]. However, how the Fu is differentially regulated in GSCs and CBs remains unclear. Here we report that a niche-dependent feedback loop involving Tkv and Fu produces a steep gradient of BMP activity and determines GSC fate. Importantly, we show that Fu and graded BMP activity dynamically develop within an intermediate cell, the precursor of CBs, during GSC-to-CB transition. Our mathematic modeling reveals a bistable behavior of the feedback-loop system in controlling thebamtranscriptional on/off switch and determining GSC fate.
登录
查看更多内容
影响因子：
4.6
作者：
M. de Cuevas;J. K. Lee;A. Spradling
通讯作者：
M. de Cuevas;J. K. Lee;A. Spradling
影响因子：
9.2
作者：
Szakmary, A;Cox, DN;Lin, HF
通讯作者：
Lin, HF
影响因子：
44.1
作者：
Hailong Wang;Yanjun Mu;Dahua Chen
通讯作者：
Hailong Wang;Yanjun Mu;Dahua Chen
果蝇雄性生殖系中不对称干细胞分裂和生态位的功能。
影响因子：
2.1
作者：
Yamashita,YukikoM;Fuller,MargaretT
通讯作者：
Fuller,MargaretT
影响因子：
64.5
作者：
Xie, T;Spradling, AC
通讯作者：
Spradling, AC