High spontaneous rate of gene duplication in Caenorhabditis elegans.
High spontaneous rate of gene duplication in Caenorhabditis elegans.
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DOI：
10.1016/j.cub.2011.01.026
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发表时间：
2011-02-22
期刊：
影响因子：
9.2
通讯作者：
Bergthorsson, Ulfar
中科院分区：
文献类型：
--
作者：
Lipinski, Kendra J.;Farslow, James C.;Fitzpatrick, Kelly A.;Lynch, Michael;Katju, Vaishali;Bergthorsson, Ulfar
基因和基因组复制是新基因和新功能的主要来源，并在基因组和生物体复杂性的进化中发挥了关键作用。基因复制的自发速率是理解基因复制的进化动力学的关键参数，但很少有直接的经验估计存在，差异很大。在测序的基因组中存在大量的最近衍生的基因重复表明自发起源的高比率，也证明了人口基因组研究报告猖獗的拷贝数多态性在种内水平。使用阵列比较基因组杂交技术分析秀丽隐杆线虫的长期突变积累系的基因拷贝数变化，首次直接估计了多细胞真核生物中基因组范围内的基因复制率。C.线虫的复制率相当高，大约为10 - 7个复制/基因/代。该速率比该物种中每个核苷酸位点的自发点突变速率大两个数量级，并且也大大超过了先前从测序的C中现存基因重复的频率分布得出的估计。线虫基因组
Gene and genome duplications are the primary source of new genes and novel functions and have played a pivotal role in the evolution of genomic and organismal complexity. The spontaneous rate of gene duplication is a critical parameter for understanding the evolutionary dynamics of gene duplicates; yet few direct empirical estimates exist and differ widely. The presence of a large population of recently derived gene duplicates in sequenced genomes suggests a high rate of spontaneous origin, also evidenced by population-genomic studies reporting rampant copy-number polymorphism at the intraspecific level. An analysis of long-term mutation-accumulation lines of Caenorhabditis elegans for gene copy-number changes using array Comparative Genomic Hybridization yields the first direct estimate of the genome-wide rate of gene duplication in a multicellular eukaryote. The gene duplication rate in C. elegans is quite high, on the order of 10−7 duplications/gene/generation. This rate is two orders of magnitude greater than the spontaneous rate of point mutation per nucleotide site in this species and also greatly exceeds an earlier estimate derived from the frequency distribution of extant gene duplicates in the sequenced C. elegans genome.
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