Prognostic value of tumor infiltrating lymphocytes combined with PD-L1 expression for patients with solitary colorectal cancer liver metastasis.
Prognostic value of tumor infiltrating lymphocytes combined with PD-L1 expression for patients with solitary colorectal cancer liver metastasis.
复制标题
肿瘤浸润淋巴细胞联合PD-L1表达对孤立性结直肠癌肝转移患者的预后价值
DOI：
10.21037/atm-20-2762a
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发表时间：
2020-10
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Xiao B;Peng J;Wang Y;Deng Y;Ou Q;Wu X;Lin J;Pan Z;Zhang L
Background The aim of this study was to assess the prognostic value of CD8+ tumor infiltrating lymphocytes (TIL) combined with programmed cell death-ligand 1 (PD-L1) expression for patients with solitary colorectal cancer liver metastasis (SCLM) undergoing R0 resection Methods Patients undergoing curative hepatectomy for SCLM were reviewed. Immunohistochemical multiplex technique was used for quantifying CD8+ TIL, and immunohistochemical staining was used for assessing PD-L1 expression. The tumor immune microenvironment (TIME) was classified as strong for high CD8+ TIL and low PD-L1, weak for low CD8+ TIL and high PD-L1, and mild for the rest. Recurrence-free survival (RFS) and overall survival (OS) was compared between these groups. Results Among the 94 patients included, a high CD8+ TIL and high PD-L1 expression was observed in 51 (54.3%) and 47 (50.0%) patients, respectively. Strong, mild, and weak TIME was observed in 24 (25.5%), 42 (44.7%), and 28 (29.8%) patients, respectively. Patients with a high CD8+ TIL had a significant longer RFS than patients with a low CD8+ TIL (3-year RFS rate, 71.6% vs. 55.3%, P=0.018). The 3-year RFS rate in the strong TIME group was significantly higher than that in the mild and weak TIME groups (89.5% vs. 71.7% and 28.8%, P<0.001), as was the 3-year rate of OS (93.8% vs. 81.8% and 61.6%, P<0.001). CD8+ TIL combined with PD-L1 expression showed better predicting accuracy for RFS than CD8+ TIL alone. Conclusions The density of CD8+ TIL combined with PD-L1 expression in liver metastasis was a predictor of RFS for patients with SCLM undergoing R0 resection, and therefore can be used for guiding the postoperative treatment of these patients.
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影响因子：
24.5
作者：
Thompson ED;Zahurak M;Murphy A;Cornish T;Cuka N;Abdelfatah E;Yang S;Duncan M;Ahuja N;Taube JM;Anders RA;Kelly RJ
通讯作者：
Kelly RJ
影响因子：
6.4
作者：
Taylor, C. R.;Levenson, R. M.
通讯作者：
Levenson, R. M.
影响因子：
8.8
作者：
Aras S;Zaidi MR
通讯作者：
Zaidi MR
影响因子：
7.2
作者：
Halama N;Spille A;Lerchl T;Brand K;Herpel E;Welte S;Keim S;Lahrmann B;Klupp F;Kahlert C;Weitz J;Grabe N;Jaeger D;Zoernig I
通讯作者：
Zoernig I
影响因子：
9
作者：
Fong, Y;Fortner, J;Blumgart, LH
通讯作者：
Blumgart, LH