Long-term in vivo transmission of alpha-particle-induced chromosomal instability in murine haemopoietic cells.
Long-term in vivo transmission of alpha-particle-induced chromosomal instability in murine haemopoietic cells.
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α粒子诱导的小鼠造血细胞染色体不稳定性的长期体内传播。
DOI：
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发表时间：
1996
影响因子：
2.6
通讯作者：
E. Wright
中科院分区：
文献类型：
--
作者：
G. Watson;S. Lorimore;E. Wright
我们以前曾报道非克隆性细胞遗传学畸变的克隆后代小鼠造血干细胞照射在体外与α粒子。这些数据与干细胞中诱导的可传递染色体不稳定性一致，导致其克隆后代在许多细胞分裂后出现多种畸变。为了确定这种不稳定性是否在体内传播，从雄性小鼠获得的骨髓细胞在体外用α粒子照射并移植到雌性受体中。在再生造血系统中，我们观察到移植后1年内持续存在染色体不稳定性。研究结果表明，在供体再生干细胞中，α粒子诱导的损伤具有长期效应。
We have previously reported non-clonal cytogenetic aberrations in the clonal descendants of murine haemopoietic stem cells irradiated in vitro with alpha-particles. The data are consistent with a transmissible chromosomal instability induced in a stem cell resulting in a diversity of aberrations in its clonal progeny many cell divisions later. To determine whether this instability is transmissible in vivo, bone marrow cells obtained from the male mouse have been irradiated with alpha-particles in vitro and transplanted into female recipients. In the repopulated haemopoietic system we have observed persisting chromosomal instability up to 1 year post-transplantation. The findings demonstrate a long-lived effect of the alpha-particle-induced lesion in the donor repopulating stem cells.
5-氟尿嘧啶可以保护负责长期增殖的造血干细胞。
影响因子：
2.6
作者：
Lerner,C;Harrison,DE
通讯作者：
Harrison,DE
DOI：
10.1016/0360-3016(90)90354-m
发表时间：
1990-12-01
影响因子：
7
作者：
LITTLE, JB;GORGOJO, L;VETROVS, H
通讯作者：
VETROVS, H