New directions in modelling dysregulated reward seeking for food and drugs.
New directions in modelling dysregulated reward seeking for food and drugs.
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DOI：
10.1016/j.neubiorev.2021.10.043
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发表时间：
2022-01
影响因子：
8.2
通讯作者：
Smith RJ
中科院分区：
文献类型：
--
作者：
Brown RM;Dayas CV;James MH;Smith RJ
行为模型是行为神经科学的核心。为了研究适应不良行为（包括暴饮暴食和毒瘾）的神经机制，开发和利用专门针对奖励寻求失调的适当动物模型至关重要。食物和可卡因通常都是由啮齿类动物在奖励和稳态机制的驱动下以有规律的方式消耗的。然而，对食物和可卡因的寻求都可能失调，导致暴饮暴食和强迫性摄入模式。 2021 年国际行为神经科学会议研讨会上的演讲者利用失调的奖励寻求行为模型来研究暴饮暴食、增强线索驱动的奖励寻求、过度动机以及尽管产生负面后果仍继续使用的神经机制。在这篇综述中，我们概述了适应不良的摄入模式的例子，并探讨了最近导致行为失调的动物模型，包括压力暴露和间歇性获得奖励。最后，我们探索了食物和药物奖励寻求失调背后的特定行为和神经机制。
Behavioral models are central to behavioral neuroscience. To study the neural mechanisms of maladaptive behaviors (including binge eating and drug addiction), it is essential to develop and utilize appropriate animal models that specifically focus on dysregulated reward seeking. Both food and cocaine are typically consumed in a regulated manner by rodents, motivated by reward and homeostatic mechanisms. However, both food and cocaine seeking can become dysregulated, resulting in binge-like consumption and compulsive patterns of intake. The speakers in this symposium for the 2021 International Behavioral Neuroscience Meeting utilize behavioral models of dysregulated reward-seeking to investigate the neural mechanisms of binge-like consumption, enhanced cue-driven reward seeking, excessive motivation, and continued use despite negative consequences. In this review, we outline examples of maladaptive patterns of intake and explore recent animal models that drive behavior to become dysregulated, including stress exposure and intermittent access to rewards. Lastly, we explore select behavioral and neural mechanisms underlying dysregulated reward-seeking for both food and drugs.
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影响因子：
5
作者：
Arnsten, Amy F T;Raskind, Murray A;Taylor, Fletcher B;Connor, Daniel F
通讯作者：
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影响因子：
2.5
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DOI：
10.1080/14640748108400816
发表时间：
1981-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
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通讯作者：
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3.4
作者：
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3.8
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