Mechanisms and biomarkers of cancer-associated thrombosis.
Mechanisms and biomarkers of cancer-associated thrombosis.
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DOI：
10.1016/j.trsl.2020.06.012
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
McCrae KR
中科院分区：
文献类型：
--
作者：
Kim AS;Khorana AA;McCrae KR
癌症相关血栓形成是癌症患者非癌症死亡的主要原因，包括动脉和静脉血栓栓塞。发生VTE的风险因素有多种，包括癌症类型、分期、治疗和其他医学合并症，这表明血栓形成的病因是多因素的。虽然癌症相关的血栓形成可以用抗凝治疗，但治疗的益处必须与癌症患者出血风险增加相平衡。虽然存在原发性和复发性VTE的风险模型，但需要额外的预测因子来改善模型性能和区分高危患者。本文将概述癌症患者血栓形成的不同机制，并概述血栓形成风险研究的生物标志物和选择候选生物标志物时的重要考虑因素。
Cancer-associated thrombosis is a leading cause of non-cancer death in cancer patients and is comprised of both arterial and venous thromboembolism. There are multiple risk factors for developing VTE, including cancer type, stage, treatment, and other medical comorbidities, which suggests that the etiology of thrombosis is multifactorial. While cancer-associated thrombosis can be treated with anticoagulation, benefits of therapy must be balanced with the increased bleeding risks seen in patients with cancer. Although risk models exist for primary and recurrent VTE, additional predictors are needed to improve model performance and discrimination of high-risk patients. This review will outline the diverse mechanisms driving thrombosis in cancer patients, as well as provide an overview of biomarkers studied in thrombosis risk and important considerations when selecting candidate biomarkers.
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影响因子：
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作者：
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DOI：
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