The Impact of BK Channels on Cellular Excitability Depends on their Subcellular Location.
The Impact of BK Channels on Cellular Excitability Depends on their Subcellular Location.
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BK 通道对细胞兴奋性的影响取决于其亚细胞位置。
DOI：
10.3389/fncel.2016.00206
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发表时间：
2016
影响因子：
5.3
通讯作者：
Stuart GJ
中科院分区：
文献类型：
--
作者：
Bock T;Stuart GJ
大电导钙活化钾通道（BK通道）在中枢神经系统中发挥着多种作用。在许多神经元细胞类型的胞体中，它们控制动作电位（AP）复极化的速度，因此它们可以对神经元的兴奋性产生影响。由于它们存在于神经末梢，它们也调节递质的释放。BK通道也被证明存在于一些神经元的树突中，在那里它们可以调节树突突的大小和持续时间。在这里，我们研究了调节不同位置的BK通道的激活对皮层第5层锥体神经元细胞兴奋性的影响。我们发现体细胞BK通道有助于胞体AP的再极化并介导快速超极化，而树突BK通道则负责树突钙峰的再极化，从而调节体细胞AP的突发放电。我们没有发现树突BK通道在反向传播AP振幅或持续时间调节中的作用的证据。这些实验强调了BK通道在调节神经元兴奋性中的不同作用，并表明它们的功能影响取决于它们的亚细胞位置。
Large conductance calcium-activated potassium channels (or BK channels) fulfil a multitude of roles in the central nervous system. At the soma of many neuronal cell types they control the speed of action potential (AP) repolarization and therefore they can have an impact on neuronal excitability. Due to their presence in nerve terminals they also regulate transmitter release. BK channels have also been shown to be present in the dendrites of some neurons where they can regulate the magnitude and duration of dendritic spikes. Here, we investigate the impact of modulating the activation of BK channels at different locations on the cellular excitability of cortical layer 5 pyramidal neurons. We find that while somatic BK channels help to repolarize APs at the soma and mediate the fast after-hyperpolarization, dendritic BK channels are responsible for repolarization of dendritic calcium spikes and thereby regulate somatic AP burst firing. We found no evidence for a role of dendritic BK channels in the regulation of backpropagating AP amplitude or duration. These experiments highlight the diverse roles of BK channels in regulating neuronal excitability and indicate that their functional impact depends on their subcellular location.
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DOI：
10.1523/jneurosci.5284-05.2006
发表时间：
2006-05-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Rancz EA;Häusser M
通讯作者：
Häusser M
DOI：
10.1523/jneurosci.2921-12.2013
发表时间：
2013-02-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Indriati DW;Kamasawa N;Matsui K;Meredith AL;Watanabe M;Shigemoto R
通讯作者：
Shigemoto R
影响因子：
16.2
作者：
Isaacson, JS;Murphy, GJ
通讯作者：
Murphy, GJ
影响因子：
5.5
作者：
Larkum, ME;Zhu, JJ;Sakmann, B
通讯作者：
Sakmann, B
影响因子：
3.4
作者：
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通讯作者：
Berger, T