Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.
Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.
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DOI：
10.1084/jem.190.6.793
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发表时间：
1999-09-20
期刊：
影响因子：
--
通讯作者：
Moretta A
中科院分区：
文献类型：
--
作者：
Falco M;Biassoni R;Bottino C;Vitale M;Sivori S;Augugliaro R;Moretta L;Moretta A
在这项研究中，通过产生特异性单克隆抗体，我们确定了p75/AIRM 1（粘附抑制受体分子1），一种新的抑制性受体，主要局限于人类自然杀伤细胞。p75/AIRM 1是一种75 kD的糖蛋白，在过钒酸钠处理后，变得酪氨酸磷酸化，并与src同源性2结构域携带蛋白酪氨酸磷酸酶（SHP）-1缔合。p75/AIRM 1基因位于人类19号染色体上，编码唾液酸粘附素家族的新成员，其特征在于三个免疫球蛋白样胞外结构域（一个NH 2末端V型和两个C2型）和胞质部分中的经典免疫受体酪氨酸抑制基序（ITIM）。最高的氨基酸序列相似性已被发现与骨髓特异性CD 33分子和胎盘CD 33 L1蛋白。与其他唾液酸粘附素分子类似，p75/AIRM 1似乎介导唾液酸依赖性配体识别。
In this study, by the generation of a specific monoclonal antibody, we identified p75/AIRM1 (for adhesion inhibitory receptor molecule 1), a novel inhibitory receptor that is mostly confined to human natural killer cells. p75/AIRM1 is a 75-kD glycoprotein that, upon sodium pervanadate treatment, becomes tyrosine phosphorylated and associates to src homology 2 domain–bearing protein tyrosine phosphatase (SHP)-1. The p75/AIRM1 gene is located on human chromosome 19 and encodes a novel member of the sialoadhesin family characterized by three immunoglobulin-like extracellular domains (one NH2-terminal V-type and two C2-type) and a classical immunoreceptor tyrosine–based inhibitory motif (ITIM) in the cytoplasmic portion. The highest amino acid sequence similarity has been found with the myeloid-specific CD33 molecule and the placental CD33L1 protein. Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid–dependent ligand recognition.
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DOI：
10.1084/jem.188.5.953
发表时间：
1998-09-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Pessino A;Sivori S;Bottino C;Malaspina A;Morelli L;Moretta L;Biassoni R;Moretta A
通讯作者：
Moretta A
影响因子：
11.4
作者：
CROCKER, PR;MUCKLOW, S;BRADFIELD, P
通讯作者：
BRADFIELD, P
DOI：
10.1073/pnas.95.9.5199
发表时间：
1998-04-28
影响因子：
11.1
作者：
Lee, N;Llano, M;Geraghty, DE
通讯作者：
Geraghty, DE
影响因子：
5.4
作者：
Braud, V;Jones, EY;McMichael, A
通讯作者：
McMichael, A
影响因子：
32.4
作者：
Meyaard, L;Adema, GJ;Phillips, JH
通讯作者：
Phillips, JH