Novel naproxen-peptide-conjugated amphiphilic dendrimer self-assembly micelles for targeting drug delivery to osteosarcoma cells
Novel naproxen-peptide-conjugated amphiphilic dendrimer self-assembly micelles for targeting drug delivery to osteosarcoma cells
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新型萘普生-肽缀合的两亲性树枝状大分子自组装胶束用于靶向将药物递送至骨肉瘤细胞
DOI：
10.1039/c6ra15022e
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Guo Li
中科院分区：
文献类型：
--
作者：
Zhao Yinbo;Zeng Qi;Wu Fengbo;Li Jing;Pan Zhaoping;Shen Pengfei;Yang Lu;Xu Ting;Cai Lulu;Guo Li
The aim of the current study was to synthesize and prepare novel self-assembly micelles loaded with curcumin (Cur) based on naproxen (Nap)-conjugated amphiphilic dendrimers. The apoptosis-inducing capacity of Nap-conjugated dendrimers and curcumin, the efficiency of uptake and the potential molecular mechanism on human osteosarcoma cells were investigated. The Nap-conjugated amphiphilic dendrimers were successfully synthesized, and the corresponding Cur-loaded micelles were conventionally prepared via self-assembly. These micelles showed good drug-encapsulating capacity, physiochemical properties, and drug-release profiles. The cellular proliferation and uptake assay suggested that the Cur-M-Nap induced more apoptosis of MG-63 human osteosarcoma cells. The western blot results suggested that these Nap-modified micelles could enhance the Cur-inducing apoptosis, mainly via intrinsic pathways and inhibition of the inflammation pathway. In summary, the Cur-loaded amphiphilic dendrimer-based micelles were successfully developed and they enhanced drug delivery to MG-63 cells. Mechanistic experiments suggested that Cur loaded into amphiphilic dendrimer-based micelles had a higher proliferation-inhibiting ability than free Cur, and could induce more apoptosis.
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影响因子：
2.1
作者：
L. Ouyang;Junzhu Pan;Yu Zhang;Li Guo
通讯作者：
L. Ouyang;Junzhu Pan;Yu Zhang;Li Guo
影响因子：
3.7
作者：
Oprea TI;Sklar LA;Agola JO;Guo Y;Silberberg M;Roxby J;Vestling A;Romero E;Surviladze Z;Murray-Krezan C;Waller A;Ursu O;Hudson LG;Wandinger-Ness A
通讯作者：
Wandinger-Ness A
由姜黄素加载的自组装富集精氨酸RGD纳米球诱导的MG-63骨肉瘤细胞增殖的选择性抑制。
影响因子：
8
作者：
Chang R;Sun L;Webster TJ
通讯作者：
Webster TJ
影响因子：
8
作者：
Yao C;Hedrick M;Pareek G;Renzulli J;Haleblian G;Webster TJ
通讯作者：
Webster TJ
影响因子：
4.2
作者：
Yang, Seok-Jin;Lee, Seul Ah;Kim, Do Kyung
通讯作者：
Kim, Do Kyung