Safety of primed repetitive transcranial magnetic stimulation and modified constraint-induced movement therapy in a randomized controlled trial in pediatric hemiparesis.
Safety of primed repetitive transcranial magnetic stimulation and modified constraint-induced movement therapy in a randomized controlled trial in pediatric hemiparesis.
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DOI：
10.1016/j.apmr.2014.09.012
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发表时间：
2015-04
影响因子：
4.3
通讯作者：
Carey, James R.
中科院分区：
文献类型：
--
作者：
Gillick, Bernadette T.;Krach, Linda E.;Feyma, Tim;Rich, Tonya L.;Moberg, Kelli;Menk, Jeremiah;Cassidy, Jessica;Kimberley, Teresa;Carey, James R.
探讨6hz启动低频重复经颅磁刺激（rTMS）与改良约束诱导运动疗法（mCIMT）联合干预对侧半球儿童先天性偏瘫的安全性。1期随机、双盲、安慰剂对照的测试前/测试后试验。大学学术设施和儿科专科医院。19例8至17岁的缺血性中风或脑室周围白质软化所致先天性偏瘫患者。没有受试者因不良事件退出。所有受试者均完成了研究。受试者被随机分为两组：rTMSreal + mCIMT （n = 10）或rTMSsham + mCIMT （n = 9）。不良事件、医师评估、同侧手功能、立体认知、认知功能、受试者报告症状评估和受试者问卷。未发生重大不良事件。两组均有轻微不良事件发生。最常见的是头痛（真实：50%，假：89%，p=0.14）和石膏刺激（真实：30%，假：44%，p= 0.65）。在二次认知和未受影响的手部运动测量中，各组之间没有差异。启动rTMS可以安全地与mCIMT一起用于先天性偏瘫。我们提供了rTMS联合mCIMT治疗儿童的新信息。这些发现对先天性偏瘫患者的功能改善具有重要的临床应用价值。
To investigate the safety of combining 6-Hz primed low-frequency repetitive transcranial magnetic stimulation (rTMS) intervention in the contralesional hemisphere with a modified constraint-induced movement therapy (mCIMT) program in children with congenital hemiparesis. Phase 1 randomized, double-blinded, placebo-controlled pretest/posttest trial. University academic facility and a pediatric specialty hospital. Nineteen subjects aged 8 to 17 years with congenital hemiparesis due to ischemic stroke or periventricular leukomalacia. No subject withdrew due to adverse events. All subjects included completed the study. Subjects were randomized to one of two groups: either rTMSreal with mCIMT (n = 10) or rTMSsham with mCIMT (n = 9). Adverse events, physician assessment, ipsilateral hand function, stereognosis, cognitive function, subject report of symptoms assessment and subject questionnaire. No major adverse events occurred. Minor adverse events were found in both groups. The most common were headaches (real: 50%, sham: 89%, p=0.14) and cast irritation (real: 30%, sham: 44%, p = 0.65). No differences between groups in secondary cognitive and unaffected hand motor measures were found. Primed rTMS can be used safely with mCIMT in congenital hemiparesis. We provide new information on the use of rTMS in combination with mCIMT in children. These findings could be useful in research and future clinical applications in advancing function in congenital hemiparesis.
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影响因子：
4.2
作者：
Carey, James R.;Evans, Chad D.;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro
影响因子：
48
作者：
Kirton, Adam;Chen, Robert;deVeber, Gabrielle
通讯作者：
deVeber, Gabrielle
影响因子：
1.9
作者：
Kakuda, Wataru;Abo, Masahiro;Umemori, Takuma
通讯作者：
Umemori, Takuma
影响因子：
5.3
作者：
Gersner, Roman;Kravetz, Elena;Zangen, Abraham
通讯作者：
Zangen, Abraham
影响因子：
3.8
作者：
Kirton, Adam;deVeber, Gabrielle;Chen, Robert
通讯作者：
Chen, Robert