Stop helping pathogens: engineering plant susceptibility genes for durable resistance.

Stop helping pathogens: engineering plant susceptibility genes for durable resistance.
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DOI:
10.1016/j.copbio.2021.05.005
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发表时间:
2021-08
影响因子:
7.7
通讯作者:
Van den Ackerveken G
Van den Ackerveken G
中科院分区:
工程技术1区
文献类型:
--
作者:
Garcia-Ruiz H;Szurek B;Van den Ackerveken G

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为了确保世界粮食生产并使农业更加可持续,迫切需要保护农作物免受疾病侵害的替代方案。迄今为止使用的对病原体的遗传抗性主要基于单一显性抗性基因,该基因介导对入侵者的特异性识别,并且通常会被病原体变体迅速破坏。植物易感性(S)基因的扰动提供了一种替代方案,为植物提供更持久的隐性抗性。 S基因能够引起植物病害,它们的失活为作物的抗性育种提供了机会。然而,S 基因功能的丧失可能会产生多效性效应。基因组编辑技术的发展有望提供强大的方法来精确干扰作物 S 基因功能并减少权衡。
Alternatives to protect crops against diseases are desperately needed to secure world food production and make agriculture more sustainable. Genetic resistance to pathogens utilized so far is mostly based on single dominant resistance genes that mediate specific recognition of invaders and that is often rapidly broken by pathogen variants. Perturbation of plant susceptibility (S) genes offers an alternative providing plants with recessive resistance that is proposed to be more durable. S genes enable the establishment of plant disease, and their inactivation provides opportunities for resistance breeding of crops. However, loss of S gene function can have pleiotropic effects. Developments in genome editing technology promise to provide powerful methods to precisely interfere with crop S gene functions and reduce tradeoffs.
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