Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction
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DOI：
10.3390/molecules16108745
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发表时间：
2011-10-19
期刊：
影响因子：
4.6
通讯作者：
Kang TR
中科院分区：
文献类型：
--
作者：
Xie YM;Yao YQ;Sun HB;Yan TT;Liu J;Kang TR
An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
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