Risks of and From SARS-CoV-2 Infection and COVID-19 in People With Diabetes: A Systematic Review of Reviews.
Risks of and From SARS-CoV-2 Infection and COVID-19 in People With Diabetes: A Systematic Review of Reviews.
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DOI：
10.2337/dc21-0930
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发表时间：
2021-12
期刊：
影响因子：
16.2
通讯作者：
Khunti K
中科院分区：
文献类型：
--
作者：
Hartmann-Boyce J;Rees K;Perring JC;Kerneis SA;Morris EM;Goyder C;Otunla AA;James OA;Syam NR;Seidu S;Khunti K
这篇综述是由世界卫生组织委托进行的，摘要介绍了关于2019年冠状病毒病(新冠肺炎)对糖尿病患者(PWD)的影响的最新研究证据。审查有关PWD感染严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)和/或其并发症(包括相关死亡)的风险增加的证据。计算机检索Cochrane新冠肺炎研究文献数据库、Embase、MEDLINE和LitCOVID，检索时间为2020年12月3日。系统综述使用了暴露于SARS-CoV-2感染的PWD的综合数据，确诊的SARS-CoV-2感染的报告数据，通过新冠肺炎入院和/或重症监护病房的住院和/或重症监护病房，以及通过新冠肺炎死亡的数据。一名审查员评估并提取数据；另一名审查员检查数据。对112篇系统综述的数据进行叙述性综合，并用效应方向图进行展示。综述提供了一致的证据，表明糖尿病是新冠肺炎严重疾病和死亡的风险因素。ICU入院时可用的数据较少，但在可用情况下，这些数据也表明风险增加。在PWD中，新冠肺炎患病前和发病期间血糖水平较高与新冠肺炎预后较差相关。与2型糖尿病相比，1型糖尿病的预后更差。没有适当的数据来辨别糖尿病是否是感染SARS-CoV-2的危险因素。由于综述问题的性质，纳入综述的大部分数据来自回溯性观察性研究。审查在多大程度上评估存在偏见的风险各不相同。目前还没有关于糖尿病是否容易感染SARS-CoV-2的数据。数据一贯表明，糖尿病会增加严重新冠肺炎的风险。由于糖尿病和新冠肺炎预后恶化都与社会经济劣势相关，它们的交集值得特别关注。
This review was commissioned by the World Health Organization and presents a summary of the latest research evidence on the impact of coronavirus disease 2019 (COVID-19) on people with diabetes (PWD). To review the evidence regarding the extent to which PWD are at increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and/or of suffering its complications, including associated mortality. We searched the Cochrane COVID-19 Study Register, Embase, MEDLINE, and LitCOVID on 3 December 2020. Systematic reviews synthesizing data on PWD exposed to SARS-CoV-2 infection, reporting data on confirmed SARS-CoV-2 infection, admission to hospital and/or to intensive care unit (ICU) with COVID-19, and death with COVID-19 were used. One reviewer appraised and extracted data; data were checked by a second. Data from 112 systematic reviews were narratively synthesized and displayed using effect direction plots. Reviews provided consistent evidence that diabetes is a risk factor for severe disease and death from COVID-19. Fewer data were available on ICU admission, but where available, these data also signaled increased risk. Within PWD, higher blood glucose levels both prior to and during COVID-19 illness were associated with worse COVID-19 outcomes. Type 1 diabetes was associated with worse outcomes than type 2 diabetes. There were no appropriate data for discerning whether diabetes was a risk factor for acquiring SARS-CoV-2 infection. Due to the nature of the review questions, the majority of data contributing to included reviews come from retrospective observational studies. Reviews varied in the extent to which they assessed risk of bias. There are no data on whether diabetes predisposes to infection with SARS-CoV-2. Data consistently show that diabetes increases risk of severe COVID-19. As both diabetes and worse COVID-19 outcomes are associated with socioeconomic disadvantage, their intersection warrants particular attention.
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影响因子：
44.5
作者：
Holman, Naomi;Knighton, Peter;Valabhji, Jonathan
通讯作者：
Valabhji, Jonathan
影响因子：
2.7
作者：
Luo L;Fu M;Li Y;Hu S;Luo J;Chen Z;Yu J;Li W;Dong R;Yang Y;Tu L;Xu X
通讯作者：
Xu X
DOI：
10.1016/j.dsx.2020.11.012
发表时间：
2020-11
期刊：
Diabetes & metabolic syndrome
影响因子：
--
作者：
Boddu SK;Aurangabadkar G;Kuchay MS
通讯作者：
Kuchay MS
影响因子：
2.6
作者：
Mair, Manish;Singhavi, Hitesh;Das, Sudip
通讯作者：
Das, Sudip
影响因子：
4.2
作者：
Du, Min;Lin, Yu-Xin;Liu, Jue
通讯作者：
Liu, Jue