New onset diabetes, type 1 diabetes and COVID-19.
New onset diabetes, type 1 diabetes and COVID-19.
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DOI：
10.1016/j.dsx.2020.11.012
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Kuchay MS
中科院分区：
文献类型：
--
作者：
Boddu SK;Aurangabadkar G;Kuchay MS
新的数据显示，2型糖尿病（T2 DM）患者患2019冠状病毒病（COVID-19）的风险更高，其严重程度和并发症也更严重。然而，缺乏关于1型糖尿病（T1 DM）的证据。本文探讨了COVID 19诱发糖尿病的可能性，并强调了COVID 19和T1 DM之间的潜在双向联系。使用相关关键词（COVID-19诱导的糖尿病; COVID-19和1型糖尿病; COVID-19诱导的DKA; SARS-CoV-2感染后新发糖尿病），在Medline（PubMed）、Scopus和Google Scholar电子数据库中进行文献检索，直至2020年10月，以提取描述COVID-19和T1 DM之间关系的相关研究。以往的经验教训和新的数据告诉我们，严重急性呼吸综合征冠状病毒（SARS-CoV和SARS-CoV-2）可通过血管紧张素转换酶-2（ACE-2）受体进入胰岛细胞，引起可逆性β细胞损伤和一过性高血糖。有关于COVID-19引发的潜在新发T1 DM的假设。本文回顾了有关COVID-19和T1 DM之间的影响和相互联系的现有证据。我们还探索了T1 DM的病毒病因学背后的机制。SARS-CoV-2可在新发糖尿病患者中引发严重的糖尿病酮症酸中毒。然而，目前还没有确凿的证据表明SARS-CoV-2会雅阁诱导T1 DM。需要对此次大流行期间新发糖尿病的儿童和成人进行长期随访，以充分了解COVID-19引起的糖尿病类型。新型冠状病毒相关死亡率不仅在2型糖尿病患者中显著更高，在1型糖尿病患者中也是如此。ACE 2在胰岛细胞中大量表达，SARS CoV 2利用其作为进入细胞的点。我们回顾了所有关于COVID-19与新发糖尿病和1型糖尿病之间的现有证据。.
New data has emerged regarding higher risk of coronavirus disease 2019 (COVID-19), and its severity and complications in patients with type 2 diabetes mellitus (T2DM). However, there is a dearth of evidence regarding type 1 diabetes mellitus (T1DM). This article explores the possibility of COVID 19 induced diabetes and highlights a potential bidirectional link between COVID 19 and T1DM. A literature search was performed with Medline (PubMed), Scopus, and Google Scholar electronic databases till October 2020, using relevant keywords (COVID-19 induced diabetes; COVID-19 and type 1 diabetes; COVID-19 induced DKA; new-onset diabetes after SARS-CoV-2 infection) to extract relevant studies describing relationship between COVID-19 and T1DM. Past lessons and new data teach us that severe acute respiratory syndrome coronaviruses (SARS-CoV and SARS-CoV-2) can enter islet cells via angiotensin converting enzyme-2 (ACE-2) receptors and cause reversible β-cell damage and transient hyperglycemia. There have been postulations regarding the potential new-onset T1DM triggered by COVID-19. This article reviews the available evidence regarding the impact and interlink between COVID-19 and Τ1DM. We also explore the mechanisms behind the viral etiology of Τ1DM. SARS-CoV-2 can trigger severe diabetic ketoacidosis at presentation in individuals with new-onset diabetes. However, at present, there is no hard evidence that SARS-CoV-2 induces T1DM on it’s own accord. Long term follow-up of children and adults presenting with new-onset diabetes during this pandemic is required to fully understand the type of diabetes induced by COVID-19. Covid-19 related mortality is significantly higher not only in people with type 2 diabetes, but also in type 1 diabetes. ACE2 is abundantly expressed in pancreatic islet cells which SARS CoV2 utilises as point of entry into the cells. We review all the available evidence regarding among COVID-19 and new-onset diabetes and type 1 diabetes mellitus. .
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