Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study.
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study.
复制标题
DOI：
10.1016/j.bone.2018.05.016
复制
发表时间：
2018-09
期刊：
影响因子：
4.1
通讯作者：
Harris TB
中科院分区：
文献类型：
--
作者：
Marques EA;Carballido-Gamio J;Gudnason V;Sigurdsson G;Sigurdsson S;Aspelund T;Siggeirsdottir K;Launer L;Eiriksdottir G;Lang T;Harris TB
在这项病例队列研究中，我们使用数据驱动的计算解剖学方法来评估与髋部骨折相关的股骨近端骨特征的性别内和性别间的空间差异。从基于人群的AGES-Reykjavik研究（平均年龄77岁）中选择了100例男性和234例女性髋部骨折病例，以及1047例随机选择的非病例亚队列参与者（562例女性）。基线-即髋部骨折前--使用基于体素的形态测量学、基于张量的形态测量学和基于表面的统计参数映射分析这些受试者的髋部定量计算机断层扫描，以评估体积骨矿物质密度（vBMD）、内部结构和皮质骨特性的空间分布（厚度，vBMD和骨内膜表面附近的骨小梁vBMD）的股骨近端，分别与髋关节骨折事件。结果显示，在男性和女性中：1）股骨颈和转子区域的上级方面（除了皮质骨厚度）一致地被确定为与髋部骨折事件相关，2）非病例和髋部骨折事件之间的骨特性差异遵循相似的趋势，位于相容区域，震级的空间分布具有不均匀性，震源区差异较大。关于性别差异，骨折组与性别之间存在显著相互作用的大多数区域显示：1）非病例组和发生髋部骨折病例组之间男性的差异更大，除皮质骨厚度外，所有骨特性的空间分布都不同，2）尽管男性病例中大多数这些区域的骨质量优于女性病例，女性病例在主要压缩组中显示出较高的vBMD，并且在包括股骨近端的前、后和外侧的几个区域中显示出较高的骨小梁内vBMD。这些研究结果表明，这些图像分析技术的价值，通过提供独特的信息与髋部骨折及其性别差异相关的骨退化的特定模式，突出了在评估髋部骨折风险时分别关注男性和女性的重要性。
In this case-cohort study, we used data-driven computational anatomy approaches to assess within and between sex spatial differences in proximal femoral bone characteristics in relation to incident hip fracture. One hundred male and 234 female incident hip fracture cases, and 1047 randomly selected noncase subcohort participants (562 female) were chosen from the population-based AGES-Reykjavik study (mean age of 77 years). The baseline –i.e. before hip fracture– hip quantitative computed tomography scans of these subjects were analyzed using voxel-based morphometry, tensor-based morphometry, and surface-based statistical parametric mapping to assess the spatial distribution of volumetric bone mineral density (vBMD), internal structure, and cortical bone properties (thickness, vBMD and trabecular vBMD adjacent to the endosteal surface) of the proximal femur, respectively, in relation to incident hip fracture. Results showed that in both men and women: 1) the superior aspect of the femoral neck and the trochanteric region (except for cortical bone thickness) were consistently identified as being associated with incident hip fracture, and 2) differences in bone properties between noncases and incident hip fracture cases followed similar trends, were located at compatible regions, and manifested heterogeneity in the spatial distribution of their magnitude with focal regions showing larger differences. With respect to sex differences, most of the regions with a significant interaction between fracture group and sex showed: 1) differences of greater magnitude in men between noncases and incident hip fracture cases with different spatial distributions for all bone properties with the exception of cortical bone thickness, and 2) that while most of these regions showed better bone quality in male cases than in female cases, female cases showed higher vBMD in the principal compressive group and higher endotrabecular vBMD at several regions including the anterior, posterior, and lateral aspects of the proximal femur. These findings indicate the value of these image analysis techniques by providing unique information about the specific patterns of bone deterioration associated with incident hip fracture and their sex differences, highlighting the importance of looking to men and women separately in the assessment of hip fracture risk.
登录
查看更多内容
影响因子：
4.1
作者：
Li, Wenjun;Kornak, John;Lang, Thomas
通讯作者：
Lang, Thomas
影响因子：
4
作者：
Freemantle, N.;Cooper, C.;Diez-Perez, A.;Gitlin, M.;Radcliffe, H.;Shepherd, S.;Roux, C.
通讯作者：
Roux, C.
影响因子：
--
作者：
Marques, Elisa A.;Mota, Jorge;Carvalho, Joana
通讯作者：
Carvalho, Joana
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
6.2
作者：
Allison, Sarah J.;Poole, Kenneth E. S.;Brooke-Wavell, Katherine
通讯作者：
Brooke-Wavell, Katherine