Origin and functions of tissue macrophages.
Origin and functions of tissue macrophages.
复制标题
DOI：
10.1016/j.immuni.2014.06.013
复制
发表时间：
2014-07-17
期刊：
影响因子：
32.4
通讯作者：
Randolph, Gwendalyn J.
中科院分区：
文献类型：
--
作者：
Epelman, Slava;Lavine, Kory J.;Randolph, Gwendalyn J.
巨噬细胞分布于全身各组织，对体内平衡与疾病均有影响。近来，有一点已变得很明确，即大多数成体组织巨噬细胞起源于胚胎发育时期，而非循环中的单核细胞。每种组织都有其独特的胚胎来源和成年来源巨噬细胞的组成，但尚不清楚不同来源的巨噬细胞在功能上是否可相互替代，或者在稳态下是否具有独特作用。这一新认识也促使人们重新思考循环单核细胞的功能。经典的Ly6C高表达单核细胞在静息器官的血管外间隙巡逻，而Ly6C低表达的非经典单核细胞则在脉管系统巡逻。炎症会促使单核细胞分化为巨噬细胞，但在炎症过程中，组织驻留巨噬细胞和新招募的巨噬细胞是否具有相似功能尚不清楚。在此，我们明确了用于识别组织巨噬细胞复杂起源的工具，并讨论了在稳态和炎症期间，组织微环境与本体起源对巨噬细胞功能调节的相对作用。
Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own composition of embryonically derived and adult-derived macrophages, but it is unclear whether macrophages of distinct origins are functionally interchangeable or have unique roles at steady state. This new understanding also prompts reconsideration of the function of circulating monocytes. Classical Ly6chi monocytes patrol the extravascular space in resting organs, and Ly6clo nonclassical monocytes patrol the vasculature. Inflammation triggers monocytes to differentiate into macrophages, but whether resident and newly recruited macrophages possess similar functions during inflammation is unclear. Here, we define the tools used for identifying the complex origin of tissue macrophages and discuss the relative contributions of tissue niche versus ontological origin to the regulation of macrophage functions during steady state and inflammation.
登录
查看更多内容
影响因子：
2.5
作者：
Caron, Justin E.;La Pine, Timothy R.;Hill, Harry R.
通讯作者：
Hill, Harry R.
巨噬细胞的局部扩散有助于与肥胖相关的脂肪组织炎症。
影响因子：
29
作者：
Amano SU;Cohen JL;Vangala P;Tencerova M;Nicoloro SM;Yawe JC;Shen Y;Czech MP;Aouadi M
通讯作者：
Aouadi M
DOI：
10.1073/pnas.1300290110
发表时间：
2013-06-04
影响因子：
11.1
作者：
Godwin, James W.;Pinto, Alexander R.;Rosenthal, Nadia A.
通讯作者：
Rosenthal, Nadia A.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
30.5
作者：
通讯作者：
--